DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	245	Identity:	90/245 - (36%)
Similarity:	141/245 - (57%)	Gaps:	13/245 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GFSNEEIRIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLSAAHCVKKLRKSKIRVIFGD 153
            |:|:   |||||..:.::|:||.|.:.:.|...||||::|..::::|||||..|...|...|
Human   212 GYSS---RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI--- 270

  Fly   154 HDQEITS--ESQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKIIKPICLPRYNYD-PA 215
             ...:.|  ::.|....|..::.|..:.|....|||||::|..|::|:::|:|:|||....: |.
Human   271 -QVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPD 334

  Fly   216 GRIGTVVGWGRTSEG-GELPSIVNQVKVPIMSITECRNQRYKSTRITSSMLCAG--RPSMDSCQG 277
            |::....|||.|.:| |:...::|...||::|...|.::......|:.||||||  ...:|||||
Human   335 GKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQG 399

  Fly   278 DSGGPLLLSNGVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWIKSNLE 327
            ||||||:......:.:||..|:|:||.....||||:||:.|:.||...:|
Human   400 DSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	86/233 (37%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133
		Tryp_SPc	216..444	CDD:214473	85/231 (37%)
		Tryp_SPc	217..447	CDD:238113	86/233 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I4057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860