DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and Tmprss2

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_056590.2	Gene:	Tmprss2 / 50528	MGIID:	1354381	Length:	490	Species:	Mus musculus

Alignment Length:	299	Identity:	98/299 - (32%)
Similarity:	157/299 - (52%)	Gaps:	53/299 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SGVSNAFGLSDTEDEVE-----YTENS-------SLKNCDCDCGFSNEEIRIVGGKPTGVNQYPW 110
            ||.::...|:.:...|:     |..:|       ||:..:|.......:.|||||.......:||
Mouse   203 SGATSFMKLNVSSGNVDLYKKLYHSDSCSSRMVVSLRCIECGVRSVKRQSRIVGGLNASPGDWPW 267

  Fly   111 MARIVYDGKFHCGGSLLTKDYVLSAAHCVKK--------------LRKSKIRVIFGDHDQEITSE 161
            ...:...|...||||::|.:::::|||||::              ||:|  .:.:|...|
Mouse   268 QVSLHVQGVHVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILRQS--LMFYGSRHQ----- 325

  Fly   162 SQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKIIKPICLPRYNYDPAGRIGT-----V 221
                   |..||.|.::|..|.||||||::|:.|::|:.::||:|||    :|...:..     :
Mouse   326 -------VEKVISHPNYDSKTKNNDIALMKLQTPLAFNDLVKPVCLP----NPGMMLDLDQECWI 379

  Fly   222 VGWGRTSEGGELPSIVNQVKVPIMSITECRNQRYKSTRITSSMLCAG--RPSMDSCQGDSGGPLL 284
            .|||.|.|.|:...::|...||::..::|.::...:..||.:|:|||  :.|:|||||||||||:
Mouse   380 SGWGATYEKGKTSDVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLV 444

  Fly   285 -LSNGVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWI 322
             |.||: ::::|..|||.||.:...||||..|:.|..||
Mouse   445 TLKNGI-WWLIGDTSWGSGCAKALRPGVYGNVTVFTDWI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	88/248 (35%)
Tmprss2	NP_056590.2	LDLa	112..147	CDD:238060
		SRCR_2	152..247	CDD:373897	9/43 (21%)
		Tryp_SPc	254..485	CDD:238113	88/248 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11120
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810