DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	108/383 - (28%)
Similarity:	184/383 - (48%)	Gaps:	70/383 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LTANYSSVLSLE------YSKGFNES-------------------DAINTIHTGHNKR--TSKFL 49
            :|.|::|.:||.      |...:|:|                   |.|.....|.::|  ..:.:
  Rat   430 ITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAM 494

  Fly    50 FD--------TIFRISSGVSNAFGLSDTEDEVE------YT----ENSSLK----NCD------- 85
            |.        ::.|:.....:....||.|...|      :|    :.|.:|    .||
  Rat   495 FQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRD 559

  Fly    86 ------CDCGFSNEEIRIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLSAAHCVKK--L 142
                  ||||......|||||..:...::||.|.:...|:..|||:|:...:|::||||.::  :
  Rat   560 GSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSM 624

  Fly   143 RKSKIRVIFGDHDQEITSESQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKIIKPICL 207
            ...::..:|....::.:.....:...|:.:..|...:.|:::.|:|||:|..|:.:|..::|:||
  Rat   625 ASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCL 689

  Fly   208 P-RYNYDPAGRIGTVVGWGRTSEGGELPSIVNQVKVPIMSITECRNQRYKSTRITSSMLCAG--R 269
            | |.::...|:...:.|||...|||...|.:.:|.|.::....| |:.|: .::|..|||||  :
  Rat   690 PARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLC-NEAYR-YQVTPRMLCAGYRK 752

  Fly   270 PSMDSCQGDSGGPLLLSN-GVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWIKSNL 326
            ...|:|||||||||:... ..::|:.|:||||:||||..:.|||:||::.:.||:..|
  Rat   753 GKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	79/233 (34%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	4/29 (14%)
		LDLa	495..525	CDD:238060	5/29 (17%)
		Ldl_recept_a	529..566	CDD:278486	5/36 (14%)
		Tryp_SPc	576..806	CDD:214473	78/231 (34%)
		Tryp_SPc	577..809	CDD:238113	79/233 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820