DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	269	Identity:	85/269 - (31%)
Similarity:	140/269 - (52%)	Gaps:	36/269 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 CDCGFSNEEIRIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLSAAHCVKK--LRKSKIR 148
            ||||......|||||..:...::||.|.:...|:..|||:|:...:|::||||.::  :..:.:.
Human   557 CDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLW 621

  Fly   149 VIFGDHDQEITSESQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKIIKPICLP-RYNY 212
            .:|.....:.:.....:...|:.::.|...:.|:::.|:|||:|..|:..|..::|:||| |.::
Human   622 TVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHF 686

  Fly   213 DPAGRIGTVVGWGRTSEGG----------------------ELPSIVNQVKVPIMSITECRN-QR 254
            ...|....:.|||...||.                      .:.:.:.:|.|.::....|.. .|
Human   687 FEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYR 751

  Fly   255 YKSTRITSSMLCAG--RPSMDSCQGDSGGPLL---LSNGVKYFIVGIVSWGVGCGREGYPGVYSR 314
            |   ::|..|||||  :...|:|||||||||:   ||.  ::|:.|:||||:||||..|.|||:|
Human   752 Y---QVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSG--RWFLAGLVSWGLGCGRPNYFGVYTR 811

  Fly   315 VSKFIPWIK 323
            ::..|.||:
Human   812 ITGVISWIQ 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	80/258 (31%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486	85/269 (32%)
		Tryp_SPc	568..822	CDD:238113	80/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40976
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820