DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and F10

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_001229297.1	Gene:	F10 / 14058	MGIID:	103107	Length:	493	Species:	Mus musculus

Alignment Length:	326	Identity:	113/326 - (34%)
Similarity:	174/326 - (53%)	Gaps:	38/326 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 YSKGFNESDAINT-------IHTGHNKR-----TSKFLFDTIFRISSGVSNAFGLSDTEDEVE-- 74
            |..|.:....|:|       |.||..||     ||    |:...:...:.:...||.||:.:|
Mouse   167 YFLGNDGKSCISTAPFPCGKITTGRRKRSVALNTS----DSELDLEDALLDEDFLSPTENPIELL 227

  Fly    75 -YTENSSLKNCDCDCGFSNEEIRIVGGKPTGVNQYPWMARIV-YDGKFHCGGSLLTKDYVLSAAH 137
             ..|....::       |::.:|||||:.....:.||.|.:: .|.:..|||::|.:.|:|:|||
Mouse   228 NLNETQPERS-------SDDLVRIVGGRECKDGECPWQALLINEDNEGFCGGTILNEFYILTAAH 285

  Fly   138 CVKKLRKSKIRVIFGDHDQEITSESQAIQRAVTAVIKHKSFDPDTYNNDIALLRLRKPISFSKII 202
            |:.:.|:.|:||  ||.:.| ..|...:...|..||||..|..|||:.|||:|||:.||:|...:
Mouse   286 CLHQARRFKVRV--GDRNTE-KEEGNEMVHEVDVVIKHNKFQRDTYDYDIAVLRLKTPITFRMNV 347

  Fly   203 KPICLPRYNYDPA----GRIGTVVGWGRTSEGGELPSIVNQVKVPIMSITECRNQRYKSTRITSS 263
            .|.|||:.::..:    .:.|.|.|:|||.|.|...:|:..::||.:....|:..  .|..||.:
Mouse   348 APACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILKMLEVPYVDRNTCKLS--TSFSITQN 410

  Fly   264 MLCAGRPSM--DSCQGDSGGPLLLSNGVKYFIVGIVSWGVGCGREGYPGVYSRVSKFIPWIKSNL 326
            |.|||..:.  |:||||||||.:......|::.||||||.||.|:|..|:|::|:.|:.||..::
Mouse   411 MFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVSWGEGCARKGKYGIYTKVTTFLKWIDRSM 475

  Fly   327 E 327
            :
Mouse   476 K 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	93/234 (40%)
F10	NP_001229297.1	GLA	36..97	CDD:214503
		EGF_CA	98..134	CDD:238011
		FXa_inhibition	141..176	CDD:291342	2/8 (25%)
		Tryp_SPc	243..471	CDD:214473	92/232 (40%)
		Tryp_SPc	244..473	CDD:238113	93/233 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3752
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H30976
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11114
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4142
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940