DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and tmprss6

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	277	Identity:	89/277 - (32%)
Similarity:	139/277 - (50%)	Gaps:	46/277 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ENSSLKNC-------DCDCGFSNEEIRIVGGKPTGVNQYPWMARIVYDGKFHCGGSLLTKDYVLS 134
            |..|:.:|       :|.||.....||:|||......::||.|.:...|:..|||:|:...::|:
Frog   544 ECDSIADCPDGSDENNCGCGIQAVGIRLVGGTQAQEGEWPWQASLQVRGEHICGGTLVADQWILT 608

  Fly   135 AAHC---------------VKKLRKSKIRVIFGDHDQEITSESQAIQRAVTAVIKHKSFDPDTYN 184
            ||||               :.|:|.|:             |..:.:...|..::.|..:|.|:::
Frog   609 AAHCFTPESYASPEVWTVYLGKVRLSR-------------STQKELAFKVIRLVIHPFYDEDSHD 660

  Fly   185 NDIALLRLRK--PISFSKIIKPICLPRYNYD-PAGRIGTVVGWGRTSEGGELPSIVNQVKVPIMS 246
            .|:||:.|..  |:: |..::|||||...:. |.|....|.|||...|.|....::.:|.:.:::
Frog   661 YDVALVLLDHLVPLT-SPHVQPICLPSSTHHFPTGSSCWVTGWGSVKENGPTSDVLQKVDIQLVA 724

  Fly   247 ITECRN-QRYKSTRITSSMLCAG--RPSMDSCQGDSGGPLLLSNGV-KYFIVGIVSWGVGCGREG 307
            ...|.. .||   :|:..|||||  ..|.|:||||||.||:..... ::|..|:||||.|||...
Frog   725 QDICTELYRY---QISPRMLCAGYRDGSKDACQGDSGSPLVCKTASGRWFQAGLVSWGAGCGIPR 786

  Fly   308 YPGVYSRVSKFIPWIKS 324
            |.|||||:::.:.||:|
Frog   787 YFGVYSRITRLVQWIES 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	81/250 (32%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060	3/15 (20%)
		Tryp_SPc	572..804	CDD:238113	81/249 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920