DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11836 and tmprss3a

DIOPT Version :9

Sequence 1:	NP_001356925.1	Gene:	CG11836 / 43007	FlyBaseID:	FBgn0039272	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	XP_021334565.1	Gene:	tmprss3a / 100000148	ZFINID:	ZDB-GENE-070912-70	Length:	543	Species:	Danio rerio

Alignment Length:	345	Identity:	103/345 - (29%)
Similarity:	162/345 - (46%)	Gaps:	54/345 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLTANYSSVLSLEYSKGFNESDAI-----------NTIHTGHNKRTSKFLFDTIFRISSGVSNA 63
            |....:.|:...|.||: |.||.|:           |.|..|.|:        |.|:....:.|
Zfish   212 WNSNLSLSACKQLGYSR-FVESKALPLSFIEQDYQNNLISIGLNQ--------TSFQQPVKIHN- 266

  Fly    64 FGLSDTEDEVEYTENSSLKNCDCD---------CG----FSNEEIRIVGGKPTGVNQYPWMARIV 115
                        ..|||...|...         ||    ||   .|||||..:...|:||...:.
Zfish   267 ------------ITNSSKTKCSLGMVTALKCIACGSRPKFS---ARIVGGNLSAEGQFPWQVSLH 316

  Fly   116 YDGKFHCGGSLLTKDYVLSAAHCVKKLRKSKIRVIFGDHDQEITSESQAIQRAVTAVIKHKSFDP 180
            :..:..||||::|..::|:|||||..:......:::....:...:..:|.  ||..:|.|..:.|
Zfish   317 FQNEHLCGGSIITSRWILTAAHCVYGIAYPMYWMVYAGLTELPLNAVKAF--AVEKIIYHSRYRP 379

  Fly   181 DTYNNDIALLRLRKPISFSKIIKPICLPRYNYD-PAGRIGTVVGWGRTSEGGELPSIVNQVKVPI 244
            ...::||||::|.:|::|:.:::|||||.:... ..|::..:.|||.|.:||:.....:...||:
Zfish   380 KGLDHDIALMKLAQPLTFNGMVEPICLPNFGEQFEDGKMCWISGWGATEDGGDASVSQHCASVPL 444

  Fly   245 MSITECRNQRYKSTRITSSMLCAG--RPSMDSCQGDSGGPLLLSNGVKYFIVGIVSWGVGCGREG 307
            :|...|.........:|:.|:|||  ....|||||||||||...:...:.:||..|||.||..:.
Zfish   445 ISNKACSQPEVYQGYLTAGMICAGYLDGGTDSCQGDSGGPLACEDSSIWKLVGATSWGQGCAEKN 509

  Fly   308 YPGVYSRVSKFIPWIKSNLE 327
            .||||:|:::.:.||...:|
Zfish   510 KPGVYTRITQSLTWIHLQME 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11836	NP_001356925.1	Tryp_SPc	97..325	CDD:238113	77/230 (33%)
tmprss3a	XP_021334565.1	LDLa	154..186	CDD:238060
		SRCR_2	191..292	CDD:317845	22/101 (22%)
		Tryp_SPc	298..525	CDD:238113	76/228 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4005
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6379
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860