DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stt3B and Stt3b

DIOPT Version :9

Sequence 1:	NP_524494.1	Gene:	Stt3B / 43005	FlyBaseID:	FBgn0011336	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_077184.2	Gene:	Stt3b / 68292	MGIID:	1915542	Length:	823	Species:	Mus musculus

Alignment Length:	771	Identity:	552/771 - (71%)
Similarity:	642/771 - (83%)	Gaps:	16/771 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFD 74
            |:.||:.||::|.||.:||||||||||||||||||||||||||||||:|.::..:|:|.||||||
Mouse    60 SQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPWFNYRSTHHLASHGFYEFLNWFD 124

  Fly    75 ERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKEL 139
            ||||||||||||||||||||||:|.|||:|:.|||.|||||:||||||.|||||||||:|||:||
Mouse   125 ERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNITVHIRDVCVFLAPTFSGLTSISTFLLTREL 189

  Fly   140 WSAGAGLFAASFIAIVPGYISRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYF 204
            |:.||||.||.||||||||||||||||:||||||||||||||:|||:|||||||||:....||||
Mouse   190 WNQGAGLLAACFIAIVPGYISRSVAGSFDNEGIAIFALQFTYYLWVKSVKTGSVFWTMCCCLSYF 254

  Fly   205 YMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHM 269
            ||||||||||||||||||||||||:|.|||.|:..:||||||:||:.||||||||||||||||||
Mouse   255 YMVSAWGGYVFIINLIPLHVFVLLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVGFQPIRTSEHM 319

  Fly   270 AALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSL 334
            ||.|||.||.|.|.|::|:..|::.||:.||.:|..|....||::|:.||..|.:||||||||||
Mouse   320 AAAGVFALLQAYAFLQYLRDRLTKQEFQTLFFLGVSLAAGAVFLSVIYLTYTGYIAPWSGRFYSL 384

  Fly   335 WDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVY 399
            ||||||||||||||||||||||||.|||||||||||.||.|:|:|||.||||||||.||||||||
Mouse   385 WDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFCIKNINDERVFVALYAISAVY 449

  Fly   400 FAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIEKK---TL 461
            |||||||||||||||||||:.:|||.:.:.:|.:|..:.       ...|:::.|..:|:   .|
Mouse   450 FAGVMVRLMLTLTPVVCMLSAIAFSNVFEHYLGDDMKRE-------NPPVEDSSDEDDKRNPGNL 507

  Fly   462 YDKAGKLKHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQ 526
            ||||||::.......:.:.|:..|:||||.:.:|||||||||||||||||||||||:|||.:| .
Mouse   508 YDKAGKVRKHVTEQEKPEEGLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVLASYN-H 571

  Fly   527 DGSRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMS 591
            ||:|||||||||||:||.|||.:.|||||||||||||||||||||||||||||||||||||||||
Mouse   572 DGTRNILDDFREAYFWLRQNTDEHARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMS 636

  Fly   592 STEEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIKESDYFTDRGEFRV 656
            |.|..:|:||.||||||||||||||||||||||||||||||||||||||||:|.||||.:|||||
Mouse   637 SNETAAYKIMRSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIREGDYFTQQGEFRV 701

  Fly   657 DAEGAPALLNCLMYKLSYYRFGELKLDYRGPSGYDRTRNAVIGNKDFDLTYLEEAYTTEHWLVRI 721
            |..|:|.||||||||:|||||||::||:|.|.|:||||||.|||||....:||||:|:|||||||
Mouse   702 DKAGSPTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRNAEIGNKDIKFKHLEEAFTSEHWLVRI 766

  Fly   722 YRVKKPHEFNRPSLKTKERT---IPPANFISRKNSKRRKGYIRNRPVVVKGKRTLK 774
            |:||.|.  ||.:|..|.|.   :|...::|:|.:||::||::|:.|..|||:|.|
Mouse   767 YKVKAPD--NRETLGHKPRVTNIVPKQKYLSKKTTKRKRGYVKNKLVFKKGKKTSK 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stt3B	NP_524494.1	Stt3	10..768	CDD:224206	547/763 (72%)
Stt3B	NP_524494.1	STT3	18..514	CDD:280649	356/498 (71%)
Stt3b	NP_077184.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		STT3	68..560	CDD:280649	356/498 (71%)
		DXD motif 1. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	98..100		1/1 (100%)
		DXD motif 2. /evidence=ECO:0000250\|UniProtKB:P39007	218..220		1/1 (100%)
		SVSE motif. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	399..402		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..526		10/45 (22%)
		WWDYG motif. /evidence=ECO:0000250\|UniProtKB:P39007	601..605		3/3 (100%)
		Interacts with target acceptor peptide in protein substrate. /evidence=ECO:0000250\|UniProtKB:B9KDD4	601..603		1/1 (100%)
		DK motif. /evidence=ECO:0000250\|UniProtKB:P39007	668..675		6/6 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836876
Domainoid	1	1.000	738	1.000	Domainoid score	I98
eggNOG	1	0.900	-	-		E1_COG1287
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7387
Inparanoid	1	1.050	1136	1.000	Inparanoid score	I219
Isobase	1	0.950	-	0	Normalized mean entropy	S281
OMA	1	1.010	-	-		QHG62160
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001875
OrthoInspector	1	1.000	-	-		oto94174
orthoMCL	1	0.900	-	-		OOG6_100521
Panther	1	1.100	-	-	LDO	PTHR13872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1409
SonicParanoid	1	1.000	-	-		X1235
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740