DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stt3B and STT3B

DIOPT Version :9

Sequence 1:	NP_524494.1	Gene:	Stt3B / 43005	FlyBaseID:	FBgn0011336	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_849193.1	Gene:	STT3B / 201595	HGNCID:	30611	Length:	826	Species:	Homo sapiens

Alignment Length:	769	Identity:	556/769 - (72%)
Similarity:	645/769 - (83%)	Gaps:	12/769 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SKVAGYSSLITFAILLIAWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFD 74
            |:.||:.||::|.||.:||||||||||||||||||||||||||||||:|.::..:|:|.||||||
Human    63 SQPAGWQSLLSFTILFLAWLAGFSSRLFAVIRFESIIHEFDPWFNYRSTHHLASHGFYEFLNWFD 127

  Fly    75 ERAWYPLGRIVGGTVYPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKEL 139
            ||||||||||||||||||||||:|.|||:|:.|||.|||||:||||||.|||||||||:|||:||
Human   128 ERAWYPLGRIVGGTVYPGLMITAGLIHWILNTLNITVHIRDVCVFLAPTFSGLTSISTFLLTREL 192

  Fly   140 WSAGAGLFAASFIAIVPGYISRSVAGSYDNEGIAIFALQFTYFLWVRSVKTGSVFWSAAAALSYF 204
            |:.||||.||.||||||||||||||||:||||||||||||||:|||:|||||||||:....||||
Human   193 WNQGAGLLAACFIAIVPGYISRSVAGSFDNEGIAIFALQFTYYLWVKSVKTGSVFWTMCCCLSYF 257

  Fly   205 YMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHM 269
            ||||||||||||||||||||||||:|.|||.|:..:||||||:||:.||||||||||||||||||
Human   258 YMVSAWGGYVFIINLIPLHVFVLLLMQRYSKRVYIAYSTFYIVGLILSMQIPFVGFQPIRTSEHM 322

  Fly   270 AALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSL 334
            ||.|||.||.|.|.|::|:..|::.||:.||.:|..|....||::|:.||..|.:||||||||||
Human   323 AAAGVFALLQAYAFLQYLRDRLTKQEFQTLFFLGVSLAAGAVFLSVIYLTYTGYIAPWSGRFYSL 387

  Fly   335 WDTGYAKIHIPIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVY 399
            ||||||||||||||||||||||||.|||||||||||.||.|:|:|||.||||||||.||||||||
Human   388 WDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFCIKNINDERVFVALYAISAVY 452

  Fly   400 FAGVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAATEVDEAEDSIEKKTLYDK 464
            |||||||||||||||||||:.:|||.:.:.:|.:| .||....:..:::.|   |...:..||||
Human   453 FAGVMVRLMLTLTPVVCMLSAIAFSNVFEHYLGDD-MKRENPPVEDSSDED---DKRNQGNLYDK 513

  Fly   465 AGKL-KHRTKHDAQQDTGVSSNLKSIVILAVLMLLMMFAVHCTWVTSNAYSSPSIVLAFHNSQDG 528
            |||: ||.|:.:..:: |:..|:||||.:.:|||||||||||||||||||||||:|||.:| .||
Human   514 AGKVRKHATEQEKTEE-GLGPNIKSIVTMLMLMLLMMFAVHCTWVTSNAYSSPSVVLASYN-HDG 576

  Fly   529 SRNILDDFREAYYWLSQNTADDARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSST 593
            :|||||||||||:||.|||.:.||||||||||||||||||||||||||||||||||||||||||.
Human   577 TRNILDDFREAYFWLRQNTDEHARVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSN 641

  Fly   594 EEKSYEIMTSLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIKESDYFTDRGEFRVDA 658
            |..:|:||.:|||||||||||||||||||||||||||||||||||||||:||||||.:||||||.
Human   642 ETAAYKIMRTLDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESDYFTPQGEFRVDK 706

  Fly   659 EGAPALLNCLMYKLSYYRFGELKLDYRGPSGYDRTRNAVIGNKDFDLTYLEEAYTTEHWLVRIYR 723
            .|:|.||||||||:|||||||::||:|.|.|:||||||.|||||....:||||:|:||||||||:
Human   707 AGSPTLLNCLMYKMSYYRFGEMQLDFRTPPGFDRTRNAEIGNKDIKFKHLEEAFTSEHWLVRIYK 771

  Fly   724 VKKPHEFNRPSLKTKERT---IPPANFISRKNSKRRKGYIRNRPVVVKGKRTLK 774
            ||.|.  ||.:|..|.|.   .|...::|:|.:||::|||:|:.|..|||:..|
Human   772 VKAPD--NRETLDHKPRVTNIFPKQKYLSKKTTKRKRGYIKNKLVFKKGKKISK 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stt3B	NP_524494.1	Stt3	10..768	CDD:224206	552/761 (73%)
Stt3B	NP_524494.1	STT3	18..514	CDD:280649	360/496 (73%)
STT3B	NP_849193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		STT3	71..563	CDD:396873	360/496 (73%)
		DXD motif 1. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	101..103		1/1 (100%)
		DXD motif 2. /evidence=ECO:0000250\|UniProtKB:P39007	221..223		1/1 (100%)
		SVSE motif. /evidence=ECO:0000250\|UniProtKB:Q5HTX9	402..405		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..509		3/21 (14%)
		WWDYG motif. /evidence=ECO:0000250\|UniProtKB:P39007	604..608		3/3 (100%)
		Interacts with target acceptor peptide in protein substrate. /evidence=ECO:0000250\|UniProtKB:B9KDD4	604..606		1/1 (100%)
		DK motif. /evidence=ECO:0000250\|UniProtKB:P39007	671..678		6/6 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146931
Domainoid	1	1.000	737	1.000	Domainoid score	I100
eggNOG	1	0.900	-	-		E1_COG1287
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7387
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	1	0.950	-	0	Normalized mean entropy	S281
OMA	1	1.010	-	-		QHG62160
OrthoDB	1	1.010	-	-		D111618at33208
OrthoFinder	1	1.000	-	-		FOG0001875
OrthoInspector	1	1.000	-	-		oto90582
orthoMCL	1	0.900	-	-		OOG6_100521
Panther	1	1.100	-	-	LDO	PTHR13872
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1409
SonicParanoid	1	1.000	-	-		X1235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750