DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PQBP1 and Pqbp1

DIOPT Version :9

Sequence 1:	NP_651331.1	Gene:	PQBP1 / 43004	FlyBaseID:	FBgn0039270	Length:	231	Species:	Drosophila melanogaster
Sequence 2:	NP_001013979.2	Gene:	Pqbp1 / 302557	RGDID:	1549750	Length:	263	Species:	Rattus norvegicus

Alignment Length:	238	Identity:	59/238 - (24%)
Similarity:	78/238 - (32%)	Gaps:	90/238 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLPAALLQRLKKRGLVTKQSGAAPISEAIEEIIAENYDDDDKSGPYPYKEDTSPEPKRRSVEEK 65
            |.||.||..||.|||::....     .|..||||||:||||    |..|:
  Rat     1 MPLPVALQTRLAKRGILKHLE-----PEPEEEIIAEDYDDD----PVDYE--------------- 41

  Fly    66 FWSHRIKERIGVNESYHGYKLCPNKYNIYHKCSLYCVNKFNSSPLSQPSHRYLKRYKRLLRKYPL 130
              :.||:                                                        .|
  Rat    42 --ATRIE--------------------------------------------------------GL 48

  Fly   131 EAGWKDVYDKGCKAFYFYNSTTQTVSWLPPSHPKARITNSAAVFRRQLANSNDEFNFDTNMV--- 192
            ...|..|:|..|...|::|..|..||||.|..|...::.||...|...|::.|:...:...|
  Rat    49 PPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVSKSAKKLRNSNADAEDKSERNLEKVDRN 113

  Fly   193 QPKSSNQNE-PDEPDVFVPAKKQKS-RDLER---KIQRRRRND 230
            ..||...:| ||..........:|| |:.||   |:.|.|..|
  Rat   114 HEKSDRSHEKPDRSHEKADRNHEKSDRERERNYDKVDRERDRD 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PQBP1	NP_651331.1	WW	130..160	CDD:278809	12/29 (41%)
Pqbp1	NP_001013979.2	WW	47..78	CDD:197736	12/30 (40%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:O60828	94..263		17/63 (27%)
		5 X 7 AA approximate tandem repeats of D-R-[NS]-H-E-K-S	104..138		6/33 (18%)
		3 X 2 AA tandem repeats of [DE]-R	139..144		1/4 (25%)
		6 X 2 AA tandem repeats of [DE]-R	150..161		3/7 (43%)
		Important for interaction with TXNL4A. /evidence=ECO:0000250\|UniProtKB:O60828	243..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	81	1.000	Inparanoid score	I5111
OMA	1	1.010	-	-		QHG48631
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106865
Panther	1	1.100	-	-	LDO	PTHR21737
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060