Protein Alignment PQBP1 and PQBP1

DIOPT Version :10

• Sequence 1: NP_651331.1
• Gene: PQBP1 / 43004
• FlyBaseID: FBgn0039270
• Length: 231
• Species: Drosophila melanogaster
• Sequence 2: NP_005701.1
• Gene: PQBP1 / 10084
• HGNCID: 9330
• Length: 265
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 57/241 - (23%)
• Similarity: 76/241 - (31%)
• Gaps: 96/241 - (39%)

  Fly     1 MSLPAALLQRLKKRGLVTKQSGAAPISEAIEEIIAENYDDDDKSGPYPYKEDTSPEPKRRSVEEK 65
            |.||.||..||.|||::....     .|..||||||:||||    |..|:
Human     1 MPLPVALQTRLAKRGILKHLE-----PEPEEEIIAEDYDDD----PVDYE--------------- 41

  Fly    66 FWSHRIKERIGVNESYHGYKLCPNKYNIYHKCSLYCVNKFNSSPLSQPSHRYLKRYKRLLRKYPL 130
                                                                      ..|...|
Human    42 ----------------------------------------------------------ATRLEGL 48

  Fly   131 EAGWKDVYDKGCKAFYFYNSTTQTVSWLPPSHPKARITNSAAVFRRQLANSN---DEFNFDTNMV 192
            ...|..|:|..|...|::|:.|..||||.|..|.:.:|.||...|...|::.   |..:..::..
Human    49 PPSWYKVFDPSCGLPYYWNADTDLVSWLSPHDPNSVVTKSAKKLRSSNADAEEKLDRSHDKSDRG 113

  Fly   193 QPKSSNQNEP-----DEPDVFVPAKKQKSRDLER---KIQRRRRND 230
            ..||...:|.     |:.|   ....:..||.||   |:.|.|..|
Human   114 HDKSDRSHEKLDRGHDKSD---RGHDKSDRDRERGYDKVDRERERD 156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PQBP1	NP_651331.1	WW	130..160	CDD:459800	12/29 (41%)
PQBP1	NP_005701.1	WW	47..78	CDD:197736	1/30 (3%)
		Disordered. /evidence=ECO:0000269|PubMed:19303059	94..265		34/148 (23%)
		5 X 7 AA approximate tandem repeats of D-R-[SG]-H-D-K-S	104..138		3/33 (9%)
		3 X 2 AA tandem repeats of [DE]-R	139..144		2/4 (50%)
		7 X 2 AA tandem repeats of [DE]-R	150..163		6/12 (50%)
		Important for interaction with TXNL4A	245..255