DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment veli and Lin7b

DIOPT Version :9

Sequence 1:	NP_733076.2	Gene:	veli / 43003	FlyBaseID:	FBgn0039269	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_068526.1	Gene:	Lin7b / 60377	RGDID:	620730	Length:	207	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	152/246 - (61%)
Similarity:	171/246 - (69%)	Gaps:	51/246 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADNAEPLTLSRDVKRSIELLEKLQASGDFPTTKLAALQKVLNSDFMTSVREVYEHVYETVDIQG 65
            ||...|||.|.|||.|::||||:||.||:.|..||.|||:||.|.|.:::|||||.:|:|:||.|
  Rat     1 MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDITG 65

  Fly    66 SHDVRASATAKATVAAFAASEGHAHPRVVELPKTEEGKTRPYELRIEGIPLYHKTNTLIVKVYRP 130
            |.:|||.||||||||||.||||||||||||||||:|
  Rat    66 SAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDE----------------------------- 101

  Fly   131 RIYVSIIHLIWKALSIFNFCFSGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVN 195
                                  |||||:||||||||||||||:||||||||||||||||||||||
  Rat   102 ----------------------GLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVN 144

  Fly   196 GVSVEGENHEKAVELLKQAVGSVKLVVRYTPKVLEEMEMRFDKQRNTRRRQ 246
            |||||||:|||||||||.|.|||||||||||:||||||.||:|.|:.||||
  Rat   145 GVSVEGEHHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQ 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
veli	NP_733076.2	L27	14..66	CDD:280918	29/51 (57%)
veli	NP_733076.2	PDZ_signaling	153..223	CDD:238492	64/69 (93%)
Lin7b	NP_068526.1	Kinase interacting site. /evidence=ECO:0000250	1..13		6/11 (55%)
		L27	14..66	CDD:397114	29/51 (57%)
		PDZ_signaling	91..172	CDD:238492	74/131 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..207		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354278
Domainoid	1	1.000	135	1.000	Domainoid score	I4837
eggNOG	1	0.900	-	-		E1_KOG3550
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22648
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2769
OMA	1	1.010	-	-		QHG48622
OrthoDB	1	1.010	-	-		D1335138at2759
OrthoFinder	1	1.000	-	-		FOG0001780
OrthoInspector	1	1.000	-	-		otm45395
orthoMCL	1	0.900	-	-		OOG6_105974
Panther	1	1.100	-	-	O	PTHR14063
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1136
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770