DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment veli and lin7b

DIOPT Version :9

Sequence 1:	NP_733076.2	Gene:	veli / 43003	FlyBaseID:	FBgn0039269	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_001018569.2	Gene:	lin7b / 553768	ZFINID:	ZDB-GENE-041011-1	Length:	207	Species:	Danio rerio

Alignment Length:	246	Identity:	151/246 - (61%)
Similarity:	166/246 - (67%)	Gaps:	51/246 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADNAEPLTLSRDVKRSIELLEKLQASGDFPTTKLAALQKVLNSDFMTSVREVYEHVYETVDIQG 65
            ||...|||.|.|||.|.||||::||.||..|..||.|||:||.|.|..::|||||.:|:|:||.|
Zfish     1 MAAMTEPLCLERDVCRVIELLDRLQRSGQLPPPKLQALQRVLQSKFCAAIREVYEQLYDTLDIIG 65

  Fly    66 SHDVRASATAKATVAAFAASEGHAHPRVVELPKTEEGKTRPYELRIEGIPLYHKTNTLIVKVYRP 130
            ..:|||.|||||||||||||||||||||||||||:|
Zfish    66 GPEVRAQATAKATVAAFAASEGHAHPRVVELPKTDE----------------------------- 101

  Fly   131 RIYVSIIHLIWKALSIFNFCFSGLGFNVMGGKEQNSPIYISRIIPGGVADRHGGLKRGDQLLSVN 195
                                  |||||:||||||||||||||:||||||||.|||||||||.|||
Zfish   102 ----------------------GLGFNIMGGKEQNSPIYISRVIPGGVADRQGGLKRGDQLPSVN 144

  Fly   196 GVSVEGENHEKAVELLKQAVGSVKLVVRYTPKVLEEMEMRFDKQRNTRRRQ 246
            |||||||:|||||||||.|.||||||||||||||||||.||:|.|:.||||
Zfish   145 GVSVEGEHHEKAVELLKAAQGSVKLVVRYTPKVLEEMEARFEKMRSARRRQ 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
veli	NP_733076.2	L27	14..66	CDD:280918	29/51 (57%)
veli	NP_733076.2	PDZ_signaling	153..223	CDD:238492	62/69 (90%)
lin7b	NP_001018569.2	L27	14..63	CDD:280918	27/48 (56%)
lin7b	NP_001018569.2	PDZ_signaling	91..172	CDD:238492	72/131 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596560
Domainoid	1	1.000	134	1.000	Domainoid score	I4961
eggNOG	1	0.900	-	-		E1_KOG3550
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22648
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2896
OMA	1	1.010	-	-		QHG48622
OrthoDB	1	1.010	-	-		D1335138at2759
OrthoFinder	1	1.000	-	-		FOG0001780
OrthoInspector	1	1.000	-	-		otm25321
orthoMCL	1	0.900	-	-		OOG6_105974
Panther	1	1.100	-	-	O	PTHR14063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2983
SonicParanoid	1	1.000	-	-		X1136
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800