DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stac and Baiap3

DIOPT Version :9

Sequence 1:	NP_651329.4	Gene:	stac / 43002	FlyBaseID:	FBgn0266719	Length:	1153	Species:	Drosophila melanogaster
Sequence 2:	NP_001156742.1	Gene:	Baiap3 / 545192	MGIID:	2685783	Length:	1150	Species:	Mus musculus

Alignment Length:	1116	Identity:	271/1116 - (24%)
Similarity:	501/1116 - (44%)	Gaps:	169/1116 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LYEEILFEIFNNIGCENNEECTNS--LVEFVQDAFKIPNATHEEIYEAARLKEPPNVRLNVEIIK 187
            ||||.|:.:.:..|....::..:.  |:.::|..|...:..|.|.....:..:.|...|.|.:::
Mouse   102 LYEEALYTVLHRAGTMGPDQVDDEEVLLSYLQQVFGTSSEEHMEAIMRVKKAKAPTYALKVSVMR 166

  Fly   188 AENLMSKDSNGLSDPFVTLYL--------ESNG--SHRYN------------------SSVKPAT 224
            |:||::||.||.|||:..|.:        |.:|  ..|:.                  :.||.:|
Mouse   167 AKNLLAKDPNGFSDPYCMLGILPASSAPQEPSGQKEQRFGFRKGSKRSSPLPAKCIQVTEVKNST 231

  Fly   225 LNPIWEEHFSLPITENARDEVLIVEVWDFDAAETVKEKVNKILDVKGVKGLSKLMKEIAVTASSG 289
            |||:|:|||...|.:...|: |.:::||.|...::.|...|:.:|.|:||:::..|:|..:|.:.
Mouse   232 LNPVWKEHFLFEIDDVNTDQ-LHLDIWDHDDDVSLAEACRKLNEVIGLKGMTRYFKQIVKSARAN 295

  Fly   290 -------KHDNELIGRAAITLKSIPVSGLTVWYNLE-KGSKGRSRGSLLVNLALSAEKNKSVAVQ 346
                   .|.::.:|...|.::.:||:|...|:.|| :.|..|.:|...:.|.|...:..:|..|
Mouse   296 GTAGPTEDHTDDFLGCLNIPIREVPVAGADRWFKLEPRSSASRVQGDCHLVLKLITTQRDTVMSQ 360

  Fly   347 EHKN-------LLKLLLMYELETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAY 404
            ..::       ||..:|.:|....:..:..|.|:.|.....:...|.|||.|:|...|:..|...
Mouse   361 RGRSGFLSYLLLLSRVLRFEHRVEEPNSSSWRGELSGPGTTVLCLHGAQSNLSPLQLAVLHWQVS 425

  Fly   405 STIHETHKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRL-------LPSCFA------- 455
            |..|:|..|::.....:|              |||:..|:....|       |...|:
Mouse   426 SRHHQTRTLDYGYLLGLL--------------EDVQAHWEEAASLPQEQEESLADSFSAFSEFGL 476

  Fly   456 -VLRKLRS--KNTSDKNIIRALNEVLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDETCNIDT 517
             :||:||.  ..|:...:.|     |::|     |:..|.:.:|..:.          |.|..:|
Mouse   477 RLLRQLRDYFPATNSTAVYR-----LELL-----LKCLEKLQLFQPAF----------EICPFET 521

  Fly   518 A----IEDAINTGTREWLEHIVEGSRQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYH 578
            .    |..|:..|.|||.:.::  :.:|...:...::|..:::|..::..|||.....:..:|:.
Mouse   522 ELSMDIAAALKRGNREWYDQLL--NTKSPREQPGPQRLAGLVELADIIYEDLQLCYGVYASLFHG 584

  Fly   579 KIQLNYSAVLYLFYDSKLAEICKSIIIEVCNNIKRLDVPDDQFEYLPNLENVNMGTTLFEVYLIL 643
            .:::::..:.:...:..:||.. .::.|               |..|.: |:.:.:.|||:||.|
Mouse   585 ILKVDFFTLTFRQLERLVAEEA-WVLTE---------------ELSPKM-NLEVASGLFELYLTL 632

  Fly   644 ---KRYVQLGESLCSEPLELSNFYPWFERGVTHWLDISIIKALSRIQKAIDLDQLKAVDETVKYS 705
               :|:........|..|.|:..:..|...|..||.:...:|..|:|.|:|:|.|:.||...|:|
Mouse   633 ADTQRFWSCIPGRESRSLALAGIHTPFLPAVKLWLQVLRDQAKWRLQGAVDVDTLEPVDAASKHS 697

  Fly   706 SSAVDTLSIFYQIKIFWQQLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVENIFIADDNNK 770
            |||.........|:..|.:|.||:...:.....::..|:|...:||.:.:.::|:    ......
Mouse   698 SSAATASLCLSHIQELWVRLAWPDPSQAQGLGTQLSQDMCEASLFYTELLRKKVD----TQPGAA 758

  Fly   771 NFILSEEWCIAINNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCASTIKTVIENALDTE 835
            ...:||:.|:.:||::.:|::....::.|:       ..|..:.||.......:..:  .|||.:
Mouse   759 GEAVSEQLCVVLNNVELVRRASGQALRGLA-------WSEGASGLEGVLPRPLLSCI--QALDED 814

  Fly   836 RNQIVELIEI-VARKMAPPIRRYLAEGAEVLAKDSNSMDQ----LMMYLESSLATLYDTLNEINF 895
            .::....:.. :..||...||:|:...:  |:.||...|:    |:.||:..||.|.|.|.:.|.
Mouse   815 LHREAHTVTAHLTSKMVADIRKYIQHIS--LSPDSIQNDEAVAPLLKYLDEKLALLNDALVKENL 877

  Fly   896 QRILDGIWSELSIIMYDLIQSNLDKRRPPAFFQNLNNTLQTMMDCF-------KMGNLQTSDIKI 953
            .|:|:.:|..|...:...:.:|.|....  |:...:.||:.::..|       .:.||:....|
Mouse   878 NRVLEALWELLLQAILQALSANRDVSAD--FYGRFHFTLEALVSFFHAEGQGLPLENLRDGSYK- 939

  Fly   954 LSSIQSRLRLYSLETSDLIHQYYLERLENQKSQESSPYGQLTITA--QLTDTGLLLNILNARNLL 1016
              .:|..|||:...|.:.|.|:||::|: |:|.|.:.:|:||:..  :..:..|.:.:|:|.:||
Mouse   940 --RLQEELRLHKCSTRECIEQFYLDKLK-QRSLEQNRFGRLTVRCHYEAAEQRLAVEVLHAADLL 1001

  Fly  1017 PMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSDHQRSEKNSLIVFSI 1081
            |:|:||..|.||.....|...|..|.:.:|.|..::..|:||:.|..::.......:.:.::|::
Mouse  1002 PLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKARTLHPVYDELFHFSVPAEACRRRGACVLFTV 1066

  Fly  1082 KDKDLFGMSSQYIAESYISFADLE--ATP-------PGEQIMMNLSRPEYTDSESLRALEYRLGD 1137
            .|.|... ::.:..|:.:....:.  |.|       ||:.|.::|.||......:||.||.|. .
Mouse  1067 MDHDWLS-TNDFAGEAALGLGGISGIARPHVGGGMRPGQPITLHLRRPRAQVRSALRMLEGRT-S 1129

  Fly  1138 KQAKDFLKKLK 1148
            ::|::|:||||
Mouse  1130 REAQEFVKKLK 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stac	NP_651329.4	C2	152..317	CDD:301316	53/199 (27%)
		Membr_traf_MHD	875..971	CDD:287505	27/102 (26%)
		C2B_Munc13-like	990..1116	CDD:175976	33/136 (24%)
Baiap3	NP_001156742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..44
		C2A_Munc13-like	131..330	CDD:176058	53/199 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214		3/20 (15%)
		Membr_traf_MHD	852..954	CDD:371123	27/106 (25%)
		C2B_Munc13-like	973..1102	CDD:175976	30/129 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1328
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46249at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45999
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850