Protein Alignment stac and unc-13-4A

DIOPT Version :9

• Sequence 1: NP_651329.4
• Gene: stac / 43002
• FlyBaseID: FBgn0266719
• Length: 1153
• Species: Drosophila melanogaster
• Sequence 2: NP_001261504.1
• Gene: unc-13-4A / 38801
• FlyBaseID: FBgn0035756
• Length: 1371
• Species: Drosophila melanogaster
• Alignment Length: 1267
• Identity: 296/1267 - (23%)
• Similarity: 536/1267 - (42%)
• Gaps: 272/1267 - (21%)

  Fly    29 LQDGDDGFFEKFGSLLRQKSQIDEGVLKSSLAPLEENGSGGEEDSDESPDGTLQLSQDSECTSID 93
            :|:.|..:||.|.||..::    |....|:....|.......|:..:.|.|
  Fly   229 VQETDGSYFENFTSLGWKR----ENRRMSATRAAEARAEANPENERDPPAG-------------- 275

  Fly    94 TFATESTLASSSDKDISTSVLDSAPVMNVTDLYEEILFEIFNNIGCE----NNEECTNSLVEFVQ 154
                |.::....:|:               .||.|:|..|.|.:|..    ......:.:....|
  Fly   276 ----EESIDRQDEKE---------------KLYAEVLHTIANTVGAPAPGGQFAHYKDEMYLHAQ 321

  Fly   155 DAFKIPNATHEEIYEAARLKEPPNVRLNVEIIKAENLMSKDSNGLSDPFVTLYL--ESNGS---- 213
            .||.:....|..:..|:...:|..:.|:..:|:|:.|.:||:||.|||:..|.:  :.||.
  Fly   322 RAFGVNPDRHYRLLHASAEDKPKIIVLSAVVIEADGLEAKDANGFSDPYCMLGIQPDENGGPPVS 386

  Fly   214 ----------------------------HRYNS-------------------------------S 219
                                        ||.:|                               |
  Fly   387 PLPLPPTPRALSADMSGGFDNSATDSPPHRKHSFRLSFKRREAGRREQRDSLGGPVPAKLIKATS 451

  Fly   220 VKPATLNPIWEEHFSLPITENARDEVLIVEVWDFDAAETVKEKVNKILDVKGVKGLSKLMKEIAV 284
            :||.||.|.|.|.|...| ::...:...:::||.|....|.:.|:::.:|:||:||.:..|::..
  Fly   452 IKPHTLTPKWNEKFKFDI-DDINTDTFHLDIWDHDDESCVMDAVSRLNEVRGVRGLGRFFKQVCQ 515

  Fly   285 TASSGKHDNELIGRAAITLKSIPVSGLTVWYNLE-KGSKGRSRGSLLVNLALSAEKNKSVAVQE- 347
            :|..|..| :.:|...|.|..||.:||..|:.|| :..:...:|.:.:.|.||..::::...:|
  Fly   516 SARQGSQD-DFLGSVNIPLSEIPSTGLDAWFKLEARSHRSTVQGRIRLKLWLSTREDRNTVSEEN 579

  Fly   348 -----HK--NLLKLLLMYELETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAYS 405
                 ||  .|.::.:.:|:.|.: .::.|.|.....|..|..|.|.||.|:...||::::.|.:
  Fly   580 HEQQIHKVEQLQRVFMQHEVTTHE-PSWTWCGDLPGPALTILHQLAVQSDLSDLHCAMARYVAAA 643

  Fly   406 TIHETHKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRLLPSCFAVLRKL---------- 460
            .::.:..|:....:.:|              .||:..|:     .|:..|:.|.|
  Fly   644 KLNRSTPLDPKFLHRLL--------------SDVEKQWN-----QPNQEALSRDLEQWLADAMNG 689

  Fly   461 ---RSKN--TSDKNIIRALNE--------VLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDET 512
               ||.|  ...::|..|||.        :|..|..:..:....:|..|.|.|.|
  Fly   690 FVERSLNQIRRHRDIFPALNPPSLIRLEFLLRCLGLLGSMRAFRAVCPFNKGVRG---------- 744

  Fly   513 CNIDTAIEDAINTGTREWLEHIVEGSRQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFY 577
                 .:.:|:..|:..|.:.::..|:...|.         :...:..:.:|:|....|:..:|.
  Fly   745 -----EVVNALRKGSVMWGQTVMRESQSMPNP---------LSNFVTTLTADIQLGQTYYHALFD 795

  Fly   578 HKIQLNYSAVLYLFYDSKLAEICKSIIIEVCNNIKRLDVPD-----DQFEYLP-NLENVNMGTTL 636
            :...:.|.:::|..||:.:.|       ||.:.:....||.     .|:..|. :.|.|:  |..
  Fly   796 NTNGIQYFSIIYKQYDAMVGE-------EVYSRMAAGQVPGVRMNLSQYAVLEGDAEPVD--TKP 851

  Fly   637 FEVYLILKRYVQLGESLCSE------PLELSNFYPWFERGVTHWLDISIIKALSRIQKAIDLDQL 695
            ||::|.|:.:.||...|.::      ||.|||.:.||...:..|:.:|..|||.||:.||.:|.:
  Fly   852 FELFLALQEFCQLKRHLSAQPQPPEKPLALSNSHEWFIPTLERWMMVSKAKALQRIRAAIRMDAI 916

  Fly   696 KAVDETVKYSSSAVDTLSIFYQIKIFWQQLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVE 760
            ...:..|:||||:|||.|....||.||:.|:||:.:.:.:..:::::.:|...:.|...:
  Fly   917 CEGERIVRYSSSSVDTASTLLNIKEFWKVLNWPDEDTAIMMESQLIDVVCSAAMHYCDLI----- 976

  Fly   761 NIFIAD----DNNKNFILSEEWCIAINNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCA 821
            :..:||    :....|..|::.|:.:||::|:|::                |.|:|::      .
  Fly   977 HTALADSGYYEQQGPFRCSDDMCVTVNNVEYVRRT----------------LAEFRSD------E 1019

  Fly   822 STIKTVIENALDTERNQIVELIEIVARKMAPPIRRYLAEGAEVLAKDSNSMD------QLMMYLE 880
            ..::...:|.|::....:....|.:..|:||.::..|.:....||...:|:.      .|:.||:
  Fly  1020 QPLEESADNLLESSLTHMENRCERILSKLAPLMQMSLQKAMFHLAWSPDSLPANQAIVPLLEYLD 1084

  Fly   881 SSLATLYDTLNEINFQRILDGIWSELSIIMYDLIQSNLDKRRPPAFFQNLNNTLQTMMDCFK--- 942
            ..||.|...|...||.|.|..||..:...|...:::..:..:|..|.:.|...||.::|.|.
  Fly  1085 CHLAALNSALLTKNFNRSLRFIWKTVLGEMSRQMETGDETDKPTHFHKRLYEALQLLIDFFHAEG 1149

  Fly   943 ----MGNLQTSDIKILSSIQSRLRLYSLETSDLIHQYYLERLENQ-KSQESSPYGQLTITAQLTD 1002
                :..|.|.|   ...|:.||:.:..:|..||..:|::||..| .:...||||.|.:.|....
  Fly  1150 QGLLLECLHTED---FWRIEQRLQFHKTDTDRLIDMFYMQRLREQLMAVMPSPYGSLAVRAYFNH 1211

  Fly  1003 TGLLLNILNARNLLPMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSD 1067
            ..|.:.:|:||:::|:|.||..|.||....:|...|......:||||.::..|::|:.|..:::.
  Fly  1212 DSLCVEVLHARDVVPLDPNGFSDPFVVIELLPRRVFLHCMEQQTNVHKRTLNPVFDECFEFSVTL 1276

  Fly  1068 HQRSEKNSLIVFSIKDKDLFGMSSQYIAESYISFADLEATPPG--------------EQIMMNLS 1118
            .|...:.::|.|::.|.|:. .::.:..|:|::..::    ||              :||.:.|.
  Fly  1277 EQCLTEGAMICFTVMDHDVL-TANDFGGEAYLALGNI----PGVADYSTSVDNFHGLKQIELPLM 1336

  Fly  1119 RPEYTDSESLRALEYRLGDKQAKDFLKKLKNR 1150
            ..:...:..|:.||.|:.||||:||::|.|:|
  Fly  1337 EQKDKCNPILQILEVRVNDKQAQDFVRKQKSR 1368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stac	NP_651329.4	C2	152..317	CDD:301316	55/229 (24%)
		Membr_traf_MHD	875..971	CDD:287505	28/102 (27%)
		C2B_Munc13-like	990..1116	CDD:175976	36/139 (26%)
unc-13-4A	NP_001261504.1	C2A_Munc13-like	319..547	CDD:176058	55/229 (24%)
		Membr_traf_MHD	1075..1179	CDD:287505	28/106 (26%)
		C2B_Munc13-like	1199..1330	CDD:175976	34/135 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1328
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14787at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45999
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850