Protein Alignment stac and F54G2.1

DIOPT Version :9

• Sequence 1: NP_651329.4
• Gene: stac / 43002
• FlyBaseID: FBgn0266719
• Length: 1153
• Species: Drosophila melanogaster
• Sequence 2: NP_001024711.1
• Gene: F54G2.1 / 180562
• WormBaseID: WBGene00018837
• Length: 1265
• Species: Caenorhabditis elegans
• Alignment Length: 1248
• Identity: 283/1248 - (22%)
• Similarity: 531/1248 - (42%)
• Gaps: 253/1248 - (20%)

  Fly    28 QLQDGDDGFFEKFGSLLRQKSQIDEGVLKSSLAPLEENGSGGEEDSDESPDGTLQLSQDSECTSI 92
            ::|..|..||||.                  .||         .|.|.:.|
 Worm   139 RVQASDGNFFEKV------------------TAP---------SDGDTARD-------------- 162

  Fly    93 DTFATESTLASSSDKDISTSVLDSAPVMNVTDLYEEILFEIFNNIGCENNEECTNSLVEFVQDAF 157
            |...|...|:...||            ..:..||.|.|:.|.:.:|..:.||...||.::|::||
 Worm   163 DELYTIKNLSIVGDK------------KQIEALYVEALYTITHKLGQGDVEESQESLYKYVRNAF 215

  Fly   158 KIPNATHEEIYEAARLKEPPNVRLNVEIIKAENLMSKDSNGLSDPFV------------------ 204
            :...|.|..:.|.|:..:||:|.||:.:::|::|::||.||.||||.
 Worm   216 QGDAAVHNALMEKAKQNKPPSVLLNILLLEAKDLIAKDVNGFSDPFAMMGVVPGTRKENQPMTDS 280

  Fly   205 --------------TLYLESNG-SHRYN--------------------------SSVKPATLNPI 228
                          .|:.:.:| .||:.                          |||:..||||.
 Worm   281 AHPEKEEQEAKSPRALHGKKDGLMHRFGGSFRRKVGKKGKPQDTGTIPAKLIKASSVQKKTLNPK 345

  Fly   229 WEEHFSLPITENARDEVLIVEVWDFDAAE-TVKEKVNKILDVK-GVKGLSKLMKEIAVTASSGKH 291
            |.|.|...:.:..||: ..:::||.|..| :|.:.|:.:..:. |.||:.:..||:..:|.:...
 Worm   346 WSEKFQFTVEDVQRDQ-FHIDIWDHDDEEQSVLDAVSSLNQITGGFKGIGRYFKEVTQSARANSD 409

  Fly   292 D--NELIGRAAITLKSIPVSGLTVWYNLE-KGSKGRSRGSLLVNLALS-------AEKNKSVAVQ 346
            |  ::.:|...:.|..||..||..|:.|: :..|.:..|.:.:.:.||       .::::::.|:
 Worm   410 DCTDDFLGCINMKLAEIPPDGLEQWFTLQPRSDKSKVSGQVKLKIWLSTKEEGRAGDEDETLDVK 474

  Fly   347 EHKNLLKLLLMYEL-ETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAY-STIHE 409
            ||..||:...:||: :|.|...: |.|.:...|.:|..|||.|..||....|:.:|.|: |.||
 Worm   475 EHIELLRQFALYEIRQTGQPVRF-WDGVYPERAMIILRQHAIQGDLTDVHLAMCRWLAFHSMIH- 537

  Fly   410 THKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRLLPSCFAVLRKLRSKNT-SDKNIIRA 473
             ..::|:|....|..::.....:..|.|:.....|........|..::.:.|.|.| |.:|....
 Worm   538 -IDISFSLLYKTLQKIIDKWQPLTLDKEEEDMLTDSFSSFDSYCKRMMIEHREKFTPSKRNSGEE 601

  Fly   474 LNEVLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDETCNIDTAIEDAINTGTREWLEHIVEGS 538
            .:.::..::.::|....:....:.:..:..|               |..:.....::::..:|..
 Worm   602 FSSLIKCMRALRESPFYQKYLPYKRPFHAHL---------------ESLVVKSAEDFIDRSIESV 651

  Fly   539 RQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYHKIQLNYSAVLYLFYDSKLAE-ICKS 602
            :       |.:..:.:::|:.:|.:...|.:.| ..:.....:::||.:....:|..|.| :...
 Worm   652 Q-------DPDPCKELLQLLNIVNTQCSRFLHY-AAVIREVARIDYSQLTLNTFDRLLTEYLTSE 708

  Fly   603 IIIEVCNNIK---RLDVPDDQFEYLPNLENVNMGTTLFEVYLILKRYVQLGESLCSEPLEL---S 661
            ::.|...::|   ||....|.    ||.::      |.::..|...:|:|.....:..:.:   |
 Worm   709 LMSEKKMDLKSQMRLSAAQDP----PNEDD------LIDLMRIHMAFVELRNYRLANRVRVRDES 763

  Fly   662 NFYPWFERGVTHWLDISIIKALSRIQKAIDLDQ-LKAVDETVKYSSSAVDTLSIFYQIKIFWQQL 725
            .:|..|.:|:..:|:::..|||:|:..:..||. :......:::|||.:|...|..|..:||:::
 Worm   764 EWYAIFNKGIKKFLEVAKEKALARVHLSCQLDMPISTSSNDMRHSSSHIDICHIIEQFTVFWERV 828

  Fly   726 DWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVE--------NIFIADDNNKNFILSEEWCIAI 782
            |..:......:..::|:.:|.....|.|::...:|        ..||...      |....|.||
 Worm   829 DINDAGLKIEYTRQLVDVICEIVTVYTQKIISGLEAEGFTQELQAFIPSQ------LLHLLCAAI 887

  Fly   783 NNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCASTI------KTVIENALDT-ERN--- 837
            ||.:.:|:|| :..::|.:||:         :|..||.||.:      |:.|||.|:: |.|
 Worm   888 NNCEQVRRSL-NITEKLHMDDM---------SLAYERDASRLNGNHMWKSEIENRLESCESNICS 942

  Fly   838 QIVELIEIVARKMAPPIRRYL-----AEGAEVLAKDSNSMDQLMMYLESSLATLYDTLNEINFQR 897
            :|..::.::..:..|.:::::     :..|:::   .:|:..|...|:..|::::..|...||.|
 Worm   943 EIDRIVGLLTERRLPQMKKHVFHLAWSPSAQLV---EDSLKPLTDMLDIELSSVHKNLLHRNFLR 1004

  Fly   898 ILDGIWSELSIIMYDLIQSNLDKRRPPAFFQNLNNTLQTMMDCFKMGN-------LQTSD----- 950
            ::....|.:..::.:.:..|:...  |||:..|......:::.|..|.       |.|:.
 Worm  1005 VMSAQVSIVVKLLRECVTENVGME--PAFYHRLFEAWHVLVEFFHAGGKGLSMDALDTNPEHMKL 1067

  Fly   951 IKILSSIQSRLRLYSLETSDLIHQYYLERLENQKSQESSPYGQLTITAQLTDTG--LLLNILNAR 1013
            :||||       |....|..||.:||.:.|:.|.......||.|.:.|......  |:|:|:.|:
 Worm  1068 VKILS-------LNQTPTEQLIEKYYKDLLKQQNEVSECKYGILNVRAYYNGNAQTLVLDIIGAK 1125

  Fly  1014 NLLPMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSDHQRSEKNSLIV 1078
            .::.:||||..|.||....:|..|:..||.|||.|.:||..|::|:.|..::..:..|  .:::.
 Worm  1126 QIIALDSNGLSDPFVVIEIIPKFRYPAVPVVKTKVVSKSLNPIFDETFEFHIPPNPPS--TAMLH 1188

  Fly  1079 FSIKDKDLFGMSSQYIAESYISFADLEATPPG---------EQIMMNLSRPEYTDSESLRALEYR 1134
            |::.|.| :..|:.:..|:::...|:    ||         .|..:.|.:|.....:.|..|..|
 Worm  1189 FTVMDHD-YLRSNDFAGEAFLELNDV----PGFGATGGSTLRQFNLILIQPVSNTKDVLDVLNSR 1248

  Fly  1135 LGDKQAKDFLKKL 1147
            ..||.|.:||:.:
 Worm  1249 KEDKDAVEFLRSI 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stac	NP_651329.4	C2	152..317	CDD:301316	58/227 (26%)
		Membr_traf_MHD	875..971	CDD:287505	23/107 (21%)
		C2B_Munc13-like	990..1116	CDD:175976	38/136 (28%)
F54G2.1	NP_001024711.1	C2A_Munc13-like	210..437	CDD:176058	58/227 (26%)
		Membr_traf_MHD	978..1081	CDD:287505	24/111 (22%)
		C2B_Munc13-like	1100..1226	CDD:175976	37/132 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46249at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45999
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020