Protein Alignment stac and aex-1

DIOPT Version :10

• Sequence 1: NP_651329.4
• Gene: stac / 43002
• FlyBaseID: FBgn0266719
• Length: 1153
• Species: Drosophila melanogaster
• Sequence 2: NP_740891.1
• Gene: aex-1 / 172519
• WormBaseID: WBGene00000084
• Length: 1009
• Species: Caenorhabditis elegans
• Alignment Length: 1070
• Identity: 218/1070 - (20%)
• Similarity: 402/1070 - (37%)
• Gaps: 275/1070 - (25%)

  Fly   252 DFDAAETVKEKVNKILDVKGVKGLSKLMK----------EIAVTASSGKHDN---ELIGRAAITL 303
            |.|..|::.::.::|..||  ..|::|.|          ||....||...:|   .:|.......
 Worm    20 DPDHLESIIDRFSEIFKVK--DHLNQLRKKCEKFQTFTLEIRPVGSSNCTENVYAYIIESETCRQ 82

  Fly   304 KSIPVSGLTVWYNLEKGS--------------------KGRSR-GSLLVNLALSAEKN------- 340
            ..:..:|.|   .||.||                    ||.|| .|||..|..|.:||
 Worm    83 LELKPTGTT---KLEIGSDKNVSLKFGLSQKKDSTTSKKGLSRSASLLKKLKFSDKKNLDELKIS 144

  Fly   341 ---KSVAVQEHKNLLKLLLMYELETSQVANYWWSGKFS-PNAELIRSQHAAQSGLTPFDCALS-- 399
               ..:||:::.||                  .|||.: ...:|||:.|........||..|.
 Worm   145 IFPLDIAVRKNINL------------------GSGKSTLLEMKLIRNDHRNMIQCLEFDDFLEMT 191

  Fly   400 ----QWHAYSTIHETH-----KLNFTLFNSI-----LDVVVPVITYMQNDSEDVKTFWDGVKRLL 450
                :|.|..:..|.:     ...|::|.||     :...|..:|.|
 Worm   192 RSFHEWQAQISESELYDGSLGDPTFSMFYSIAFFFEIPSFVLKLTEM------------------ 238

  Fly   451 PSCFAV----LRKLRSKNTSDKNI-IRALNEVLDI----------------LKKIKELEVPESVD 494
             :||.|    ::||..:..:|.:: :.|....:|:                ...|:.:.||.|.:
 Worm   239 -TCFLVWDDEMKKLDERALADVSLKMTACESEVDLQHPLLSPALSYLNDCTCNTIRCILVPFSTE 302

  Fly   495 -IFP-------KSVYGWLHTNDTDETCNIDTAIE--------DAINTGTREWLEHIVEGSRQSKN 543
             .||       ||:...|..  ..:.|.:|...|        :.:::..::.||...|...:|..
 Worm   303 PFFPPVSPSRLKSINVALKL--IADICVLDVWDEFENLANPSNFLSSELKKLLESSAERYGESLK 365

  Fly   544 TETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYHKIQLNYSAVLYLFYDSKLAEICKSIIIEV- 607
            .:..:|..:.::.|...:.::.|   .|:  ||:|:..:||.....|..|..|||   ||.|.:
 Worm   366 KQEFNELCRTILNLWMSLSNESQ---PYY--IFFHQFDINYIGAAMLKLDKYLAE---SIQISLK 422

  Fly   608 CN-NIKRLDVPDDQFEYLPNLENVNMGTTLFEVYLILKRYVQLGESLCSEPLELSNFYPWFERGV 671
            |. ::..|.:|.:       |||..  .|...:::.|:..:.:.|:......:|.:|..||
 Worm   423 CQLDLLNLRIPTE-------LENFT--KTTMRLFVTLRNLLNMVEAFHLPECQLFHFEEWF---- 474

  Fly   672 THWLDISII-------KALSRIQKAIDLDQLKAVDETVKYS------SSAVDTLSIFYQIKIFWQ 723
               .|||:.       ..|..:::.|.||:   ..::|||.      :.....|.|...|.....
 Worm   475 ---TDISVFWTYSWREVTLQMVERTITLDE---DGDSVKYGARRPLPAGLYSFLCIQKGISDDLA 533

  Fly   724 QLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQM-SRRVENIFIADDNNKNFI-----LSEEWCIAI 782
            :|::.......:..|.:||.:|:....||::: |..:.|   .::.....:     :.:..|
 Worm   534 RLEFTFPHHLVVCAASVVNIMCQNINAYARKLFSEAMRN---HEEKASRLVRATNGIEQAMC--- 592

  Fly   783 NNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEAERCASTIKTVIENALDTERNQI-------V 840
                ::.:....|.:       .:||.||....:.....||...::::..||...|:       |
 Worm   593 ----FVEEGYRRFAQ-------FQRLEEYVDVDDLSAVRSTSIRLLKSTRDTCEIQVSTLLSHFV 646

  Fly   841 ELIEIVARKMAPPIRRYLAEGAEVLAKDSNS-----MDQLMM--YLESSLATLYDTLNEINFQRI 898
            .|...:..|:|   :...|:|     |:|||     |.:|..  .:||.|...|..::::.. .:
 Worm   647 NLKTDIVLKIA---KNLCADG-----KESNSGLKSYMRELASSERIESILECCYGLVDDVRC-LL 702

  Fly   899 LDGIW----SELSIIMYDLIQSNLDKRRPPAFFQN-----LN----NTLQTMMDCFKMG------ 944
            |...:    ...:..:...|:.|:.:::|..::.|     ||    ..|:.|...|::.
 Worm   703 LPNCFKLSTQHFATSLEQQIRKNIRQKQPAEYYSNIYVGFLNILIFKRLKQMYLKFQIALKYIYE 767

  Fly   945 NLQTSDIKILSSIQSRLRLYSLETSDLIHQYY---LERLENQKSQESSPYGQLTIT-AQLTDTGL 1005
            .|:..|.|.: .:.|.|.|.|..|.|||..||   .|:::..:. .::|:..:.|: .::.|...
 Worm   768 FLEIEDRKDI-ELLSNLHLNSFSTKDLILSYYDSLCEKIDRTRF-GNAPHVDVHISYVKMVDEDT 830

  Fly  1006 LLNILNARNLLPMD----SNGSVDSFVKASFMPTSRF--NDVPTVKTNVHNKSCFPLYDQEFRIN 1064
            :...:....:.|::    .:..||.||:....|...|  |...:..||...:|..|.:.|.|.|.
 Worm   831 ISIQIKLIKMSPIEWIDVISDRVDYFVRLELFPKILFPSNKFESPTTNPMPQSTRPQWKQLFEIR 895

  Fly  1065 LSDHQRSEKNSLIVFSIKDKDLFGMSSQYIAESYISFADLEATP------PGEQIMMNLSRPEYT 1123
            :.......:.:.:..|:.|.:.|  ..:.:...:||   |.:.|      |.:::.:.|...:::
 Worm   896 VPLECFFLRGACLAISVFDHERF--IDRLVGRGFIS---LHSVPQASEEKPTQRLQVPLLPNDFS 955

  Fly  1124 DSESL--RALEYR-LGDKQAKDFLKKLKNR 1150
            |..::  :.|:.| ..|..||:|::....|
 Worm   956 DQNNVFYQLLKTRACRDSIAKEFIETRTRR 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stac	NP_651329.4	C2	152..317	CDD:472691	17/77 (22%)
		MUN	<637..1003	CDD:461870	81/421 (19%)
		C2B_Munc13-like	990..1116	CDD:175976	26/138 (19%)
aex-1	NP_740891.1	C2	<854..948	CDD:472691	21/98 (21%)