DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stac and Baiap3

DIOPT Version :9

Sequence 1:	NP_651329.4	Gene:	stac / 43002	FlyBaseID:	FBgn0266719	Length:	1153	Species:	Drosophila melanogaster
Sequence 2:	NP_001299592.1	Gene:	Baiap3 / 106146145	RGDID:	10059729	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	1119	Identity:	273/1119 - (24%)
Similarity:	505/1119 - (45%)	Gaps:	175/1119 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LYEEILFEIFNNIGCENNEECTNS--LVEFVQDAFKIPNATHEEIYEAARLKEPPNVRLNVEIIK 187
            ||||.|:.:.:..|....::..:.  |:.::|..|...:..|.|.....:..:.|...|.|.:::
  Rat   102 LYEEALYTVLHRAGTMGPDQVDDEEVLLSYLQQVFGSSSEEHMEAIMRVKKAKAPTYALKVSVMR 166

  Fly   188 AENLMSKDSNGLSDPFVTLYL--------ESNG--SHRYN------------------SSVKPAT 224
            |:||::||.||.|||:..|.:        ||:|  ..|:.                  :.||.:|
  Rat   167 AKNLLAKDPNGFSDPYCMLGILPASSAPQESSGQKEQRFGFRKGSKRSSPLPAKCIQVTEVKSST 231

  Fly   225 LNPIWEEHFSLPITENARDEVLIVEVWDFDAAETVKEKVNKILDVKGVKGLSKLMKEIAVTASSG 289
            |||:|:|||.|.| |:...:.|.:::||.|...::.|...|:.:|.|:||:::..|:|..:|.:.
  Rat   232 LNPVWKEHFLLEI-EDVNTDQLHLDIWDHDDDVSLAEACRKLNEVIGLKGMTRYFKQIVKSARAN 295

  Fly   290 -------KHDNELIGRAAITLKSIPVSGLTVWYNLE-KGSKGRSRGSLLVNLALSAEKNKSVAVQ 346
                   .|.::.:|...|.::.:||:|...|:.|| :.|..|.:|...:.|.|...:..:...|
  Rat   296 GTAGPTEDHTDDFLGCLNIPIREVPVAGADRWFKLEPRSSASRVQGDCHLVLKLITTQRDTAMSQ 360

  Fly   347 EHKN-------LLKLLLMYELETSQVANYWWSGKFSPNAELIRSQHAAQSGLTPFDCALSQWHAY 404
            ..::       ||..:|.:|....:..:..|.|:.|.....:...|.|||.|:|...|:..|...
  Rat   361 RGRSGFLSYLLLLSRVLRFEHRVEEPNSSSWRGELSGPGNTVLCLHGAQSNLSPLQLAVLHWQVS 425

  Fly   405 STIHETHKLNFTLFNSILDVVVPVITYMQNDSEDVKTFWDGVKRL-------LPSCFA------- 455
            |..|:|..|::.....:|              |||:..|:....|       |...|:
  Rat   426 SRHHQTRTLDYGYLLGLL--------------EDVQAHWEEAASLPQEQEESLADSFSAFSEFGL 476

  Fly   456 -VLRKLRS--KNTSDKNIIRALNEVLDILKKIKELEVPESVDIFPKSVYGWLHTNDTDETCNIDT 517
             :||:||.  ..|:...:.|     |::|     |:..|.:.:|..:.          |.|..:|
  Rat   477 RLLRQLRDYFPATNSTAVYR-----LELL-----LKCLEKLQLFQPAF----------EICPFET 521

  Fly   518 A----IEDAINTGTREWLEHIVEGSRQSKNTETDDEKLQYVIKLIQMVRSDLQRAMEYFDKIFYH 578
            .    |..|:..|.|||.:.::  :.:|...:...::|..:::|..::..|||.....:..:|:.
  Rat   522 ELSMDIAAALKRGNREWYDQLL--NAKSPREQPGPQRLAGLVELADIIYEDLQSCYGVYASLFHG 584

  Fly   579 KIQLNYSAVLYLFYDSKLAEICKSIIIEVCNNIKRLDVPDDQFEYLPNLENVNMGTTLFEVYLIL 643
            .:::::..:.:...:..:||.. .::.|               |..|.: |:.:.:.|||:||.|
  Rat   585 ILKVDFFTLTFRQLERLVAEEA-WVLTE---------------ELSPKM-NLEVASGLFELYLTL 632

  Fly   644 ---KRYVQLGESLCSEPLELSNFYPWFERGVTHWLDISIIKALSRIQKAIDLDQLKAVDETVKYS 705
               :|:........|..|.|:..:..|...|..||.:...:|..|:|.|:|:|.|:.||...|:|
  Rat   633 ADTQRFWSCIPGRESRSLALAGIHTPFLPAVKLWLQVLRDQAKWRLQGAVDVDTLEPVDAASKHS 697

  Fly   706 SSAVDTLSIFYQIKIFWQQLDWPEVEGSYIFVAKIVNDLCRCCIFYAQQMSRRVENIFIADDNNK 770
            |||.........|:..|.:|.||:...:.....::..|:|...:||.:.:.::|:    ......
  Rat   698 SSAATASLCLSHIQELWVRLAWPDPAQAQGLGTQLSQDMCEASLFYTELLRKKVD----TQPGAA 758

  Fly   771 NFILSEEWCIAINNMDYIRQSLPSFIKELSIDDIIKRLGEYRTNLEA---ERCASTIKTVIENAL 832
            ...:||:.|:.:||::.:|::....::.|:       ..|....||.   ....|:|:.:.|:.|
  Rat   759 GEAVSEQLCVVLNNVELVRRASGQALRGLA-------WSEGANGLEGVLPRPLLSSIQALDEDLL 816

  Fly   833 DTERNQIVELIEIVARKMAPPIRRYLAEGAEVLAKDSNSMDQ----LMMYLESSLATLYDTLNEI 893
            .........|    ..||...||:|:...:  |:.||...|:    |:.||:..||.|.|:|.:.
  Rat   817 REAHTVTAHL----TSKMVADIRKYVQHIS--LSPDSIQNDEAVAPLLKYLDEKLALLNDSLVKE 875

  Fly   894 NFQRILDGIWSELSIIMYDLIQSNLDKRRPPA-FFQNLNNTLQTMMDCF-------KMGNLQTSD 950
            |..|:|:.:|   .:::..::|:....|...| |:...:.||:.::..|       .:.||:...
  Rat   876 NLSRVLEALW---ELLLQAILQALSANRGVSADFYGRFHFTLEALVSFFHAEGQGLPLENLRDGS 937

  Fly   951 IKILSSIQSRLRLYSLETSDLIHQYYLERLENQKSQESSPYGQLTITA--QLTDTGLLLNILNAR 1013
            .|   .::..|||:...|.:.|.|:||::|: |:|.|.:.:|:||:..  :..:..|.:.:|:|.
  Rat   938 YK---RLEEELRLHKCSTRECIEQFYLDKLK-QRSLEQNRFGRLTVRCHYEAAEQRLAVEVLHAA 998

  Fly  1014 NLLPMDSNGSVDSFVKASFMPTSRFNDVPTVKTNVHNKSCFPLYDQEFRINLSDHQRSEKNSLIV 1078
            :|||:|:||..|.||.....|...|..|.:.:|.|..::..|:||:.|..::.......:.:.::
  Rat   999 DLLPLDANGLSDPFVIVELGPPHLFPLVRSQRTQVKARTLHPVYDELFHFSVPAEACRRRGACVL 1063

  Fly  1079 FSIKDKDLFGMSSQYIAESYISFADLE--ATP-------PGEQIMMNLSRPEYTDSESLRALEYR 1134
            |::.|.|... ::.:..|:.:....:.  |.|       ||:.|.::|.||......:||.||.|
  Rat  1064 FTVMDHDWLS-TNDFAGEAALGLGGVSGIARPHVGGGVRPGQPITLHLRRPRAQVRSALRMLEGR 1127

  Fly  1135 LGDKQAKDFLKKLK 1148
            . :::|::|:||||
  Rat  1128 T-NREAQEFVKKLK 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stac	NP_651329.4	C2	152..317	CDD:301316	55/199 (28%)
		Membr_traf_MHD	875..971	CDD:287505	26/103 (25%)
		C2B_Munc13-like	990..1116	CDD:175976	33/136 (24%)
Baiap3	NP_001299592.1	C2A_Munc13-like	131..330	CDD:176058	55/199 (28%)
		Membr_traf_MHD	853..954	CDD:287505	26/106 (25%)
		C2B_Munc13-like	973..1107	CDD:175976	32/134 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1328
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46249at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45999
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810