Protein Alignment MLLT3 and TAF14

DIOPT Version :10

• Sequence 1: NP_004520.2
• Gene: MLLT3 / 4300
• HGNCID: 7136
• Length: 568
• Species: Homo sapiens
• Sequence 2: NP_015196.1
• Gene: TAF14 / 855974
• SGDID: S000006050
• Length: 244
• Species: Saccharomyces cerevisiae
• Alignment Length: 164
• Identity: 44/164 - (26%)
• Similarity: 79/164 - (48%)
• Gaps: 15/164 - (9%)

Human    23 PTVEGF-THDWM--VFVRGPEHSNIQHFV-EKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFIL 83
            |.||.| ...|.  :.:...|...|...: :||::|||.:|..|.|...|||:::||.|:.||.|
Yeast    22 PPVENFPVRQWSIEIVLLDDEGKEIPATIFDKVIYHLHPTFANPNRTFTDPPFRIEEQGWGGFPL 86

Human    84 PIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNP--TEDFRRKLLKAGGDPNRSI 146
            .|.|:...|...||:..|.:.   |:....|.|:  .::..|.|  ||:    |.|:|.....:.
Yeast    87 DISVFLLEKAGERKIPHDLNF---LQESYEVEHV--IQIPLNKPLLTEE----LAKSGSTEETTA 142

Human   147 HTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 180
            :|.:.....:::::::...:..:.:.|:|:...|
Yeast   143 NTGTIGKRRTTTNTTAEPKAKRAKTGSASTVKGS 176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	38/119 (32%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	78..80		0/1 (0%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	106..108		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..475		5/43 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300
		AHD	503..563	CDD:436050
TAF14	NP_015196.1	TFG3	2..242	CDD:227366	44/164 (27%)