Protein Alignment MLLT3 and mllt3

DIOPT Version :10

• Sequence 1: NP_004520.2
• Gene: MLLT3 / 4300
• HGNCID: 7136
• Length: 568
• Species: Homo sapiens
• Sequence 2: XP_009301332.2
• Gene: mllt3 / 550517
• ZFINID: ZDB-GENE-050417-356
• Length: 587
• Species: Danio rerio
• Alignment Length: 600
• Identity: 393/600 - (65%)
• Similarity: 462/600 - (77%)
• Gaps: 45/600 - (7%)

Human     1 MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRV 65
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MASSGAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRV 65

Human    66 CKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTED 130
            ||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||:
Zfish    66 CKDPPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEE 130

Human   131 FRRKLLKAGG--DPNR-----------------------SIHTSSSSSSSSSSSSSSSSSSSSSS 170
            ||||||||||  ||::                       .:.|..|||.:.:.|.:..|.|...|
Zfish   131 FRRKLLKAGGQRDPHKRSSEDSKVMVMQEGSTSLFGPHLKLPTLPSSSLTLTFSDAKKSKSFPGS 195

Human   171 SSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKK 235
            ...|.|||:.:::::.||||....||.|..|:||:||||||:|.||||::.|:|..|.||: |||
Zfish   196 KDGSKSSSALTTTNNISSSSLKLHKPPKDHKDHKDKPSKDSKESKSAFRDFSKDSGKLSKD-SKK 259

Human   236 PKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITS-GQDKKAPSKRPPISDSEELSAKKRK 299
            ||||:|::|::.:|:|.|||||..|||.:  |:.|:.:| ||     |||.|:.|:|....||||
Zfish   260 PKENQPIQEDRPIPQMGFKEPKSTSKEQR--SSELSFSSLGQ-----SKRRPVLDNEGHVTKKRK 317

Human   300 KSSSEALFKSFSSAPPLILTCS---ADKKQIKDKSHVKMGKVKIESETSEKKK-STLPPFDDIVD 360
            .|.||:..|  ..|.|.:|...   :|||.:|||..::..::: .||.||||| ..||||.|::|
Zfish   318 SSFSESSQK--QQACPALLQQQHHHSDKKVLKDKPQIRHNRLQ-NSELSEKKKLQALPPFQDVLD 379

Human   361 PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQ-QGPLRSIMKDLHSDDNEEESDEVED 424
            |||||:::|..::|||:|||||||||||||.|.....|| .|||||::.|||||:|||:|:|.:|
Zfish   380 PNDSDMDDNTFTRSDSDQPSPASSSSSSSSGFGRGHKRQVLGPLRSVIPDLHSDENEEDSEEDDD 444

Human   425 NDNDSEMERPVN-RGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQS 488
            ||.||::||||: :...|.|||||||||:||:||.||||.|..||||||.::||| |||.||||:
Zfish   445 NDMDSDLERPVHTQMTHRHRRVSLSDGSESENSSGSSPLPHNDPPPLLKNSSNQI-EVKGPIKQA 508

Human   489 KSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKT 553
            |.||. ||.:|||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Zfish   509 KMDKN-KNIDCDKAYLDELVELHRRLMALRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKT 572

Human   554 TVRKLQSYLETSGTS 568
            |||||||||||:|:|
Zfish   573 TVRKLQSYLETTGSS 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	125/127 (98%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	78..80		1/1 (100%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	106..108		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..475		177/368 (48%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300		3/4 (75%)
		AHD	503..563	CDD:436050	58/59 (98%)
mllt3	XP_009301332.2	None