Protein Alignment MLLT3 and mllt3

DIOPT Version :10

• Sequence 1: NP_004520.2
• Gene: MLLT3 / 4300
• HGNCID: 7136
• Length: 568
• Species: Homo sapiens
• Sequence 2: XP_012818507.1
• Gene: mllt3 / 549668
• XenbaseID: XB-GENE-6257679
• Length: 578
• Species: Xenopus tropicalis
• Alignment Length: 585
• Identity: 441/585 - (75%)
• Similarity: 493/585 - (84%)
• Gaps: 29/585 - (4%)

Human     5 CAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDP 69
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
 Frog     2 CAVQVKLELGHRAQVRKKPTLEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDP 66

Human    70 PYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRK 134
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||:||||
 Frog    67 PYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRRK 131

Human   135 LLKAGGDPNRSIHTSSSSSSSSSSS---------SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 190
            ||||||    .:.||..||.||.:|         |.|.|....|.||..|...:...|.::||:|
 Frog   132 LLKAGG----IMVTSEGSSFSSGTSLHLPSLPCNSLSFSDVKKSKSSHGSKDPNKLVSINNSSNS 192

Human   191 TSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKE 255
            .|.|||||..||||||.||.|:||:||||||||:|||||||||||||||||||||||||||||||
 Frog   193 ISLSKPHKSSKEHKEKSSKYSKEHRSAFKEPSREHNKSSKESSKKPKENKPLKEEKIVPKMAFKE 257

Human   256 PKPMSKEPK-PDSNLLTITSG--QDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLI 317
            ||||||||: .::|:||:::|  |:||..|||||..|||:..|:|||||:||:..||||::..||
 Frog   258 PKPMSKEPRCENNNILTVSTGHQQEKKLSSKRPPHLDSEDPFARKRKKSNSESSVKSFSNSSLLI 322

Human   318 LTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPA 382
            |: |:|||.::|||..|:||||||||..:|||.:||||:|||||||:|:|:|:||||:|.|||||
 Frog   323 LS-SSDKKPLRDKSVHKIGKVKIESEVMDKKKLSLPPFEDIVDPNDTDMEDNMSSKSESGQPSPA 386

Human   383 SSSSSSSSSFTPSQTRQQ--------GPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPV-NRG 438
            |||||||||..|.....:        |.||||:|||||||||:|||:.|  |||||.||.: ..|
 Frog   387 SSSSSSSSSLAPPPHNHRQGFFVSCPGSLRSIVKDLHSDDNEDESDDAE--DNDSEGERTIYMHG 449

Human   439 GSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAY 503
            |||:||:||||||:|||||.||||.:| ||.|||||||||||||||||||||:||||||:|||||
 Frog   450 GSRARRISLSDGSNSESSSVSSPLRNE-PPTLLKTNNNQILEVKSPIKQSKSEKQIKNGDCDKAY 513

Human   504 LDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS 568
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||:|.|
 Frog   514 LDELVELHRRLMTLRERHVLQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETTGAS 578

Human   569  568
             Frog   579  578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	124/127 (98%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	78..80		1/1 (100%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	106..108		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..475		221/357 (62%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300		3/4 (75%)
		AHD	503..563	CDD:436050	58/59 (98%)
mllt3	XP_012818507.1	YEATS_AF-9_like	6..134	CDD:341125	124/127 (98%)
		AHD	513..573	CDD:436050	58/59 (98%)