Protein Alignment MLLT3 and tfg3

DIOPT Version :10

• Sequence 1: NP_004520.2
• Gene: MLLT3 / 4300
• HGNCID: 7136
• Length: 568
• Species: Homo sapiens
• Sequence 2: NP_593114.1
• Gene: tfg3 / 2541729
• PomBaseID: SPAC22H12.02
• Length: 241
• Species: Schizosaccharomyces pombe
• Alignment Length: 237
• Identity: 46/237 - (19%)
• Similarity: 78/237 - (32%)
• Gaps: 88/237 - (37%)

Human    47 FVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGH 111
            ||::|.:.||.:|..|.|..:.||::::|.|:..|.:.|.:|:.:|....:       |||.. |
pombe    53 FVDRVTYKLHPTFQNPTRTIRKPPFQIKEQGWGEFEMEIIIYYADKGGEHR-------FLHYL-H 109

Human   112 PPVNHLRCEKLTFN-NPTEDFRRKLLKAGGD-PNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSS 174
            ....|.. |.:..| |.|.....|.|.|.|: |..|
pombe   110 FQQEHYH-EDIELNINATRPGLLKALTATGEVPGYS----------------------------- 144

Human   175 SSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKEN 239
                                       :..|:..||.|:            |:|...:.||..:.
pombe   145 ---------------------------DEGEEARKDKRK------------NESEVGAGKKKAKA 170

Human   240 KPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAP 281
            ||:..:|:...:         ::.:.|..|..:....:.|.|
pombe   171 KPVDMDKLAEGL---------QKLQEDDLLQVVQMVNENKTP 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MLLT3	NP_004520.2	YEATS_AF-9_like	9..137	CDD:341125	26/90 (29%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	78..80		0/1 (0%)
		Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM	106..108		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..475		19/145 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	295..300
		AHD	503..563	CDD:436050
tfg3	NP_593114.1	TFG3	1..238	CDD:227366	46/237 (19%)