DRSC/TRiP Functional Genomics Resources

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Protein Alignment MLLT3 and Y105E8B.7

DIOPT Version :10

Sequence 1:NP_004520.2 Gene:MLLT3 / 4300 HGNCID:7136 Length:568 Species:Homo sapiens
Sequence 2:NP_493542.2 Gene:Y105E8B.7 / 190914 WormBaseID:WBGene00013692 Length:269 Species:Caenorhabditis elegans


Alignment Length:355 Identity:79/355 - (22%)
Similarity:129/355 - (36%) Gaps:114/355 - (32%)


- Green bases have known domain annotations that are detailed below.


Human     9 VKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHF-----VEKVVFHLHESFPRPKRVCKD 68
            |::.:||.:....:....|.||.|.:||: |.:.:...|     ::||.|.:||||.:|.|....
 Worm     4 VEVIVGHSSTRLPENNENGHTHKWTLFVK-PGNRDYDEFPDNKLIQKVKFEIHESFAQPVRFVTK 67

Human    69 PPYKVEESGYAGFILPIEVYFK-NKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFR 132
            ||:|:.|:|:|.|...:.::.. ..|:||.:.::..||   .|...| .|..:||..........
 Worm    68 PPFKITETGFASFTTLVTIFLNLPNEKPRTIPYELTLF---TGDQDV-QLETQKLVVQKDVPPAY 128

Human   133 RKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPH 197
            .:|:|                                                            
 Worm   129 LELIK------------------------------------------------------------ 133

Human   198 KLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKE 262
            |..:..|.|.|..|.:.||    |||..:|.:           |:|||:...||:      .|||
 Worm   134 KYARTKKRKASLISNDEKS----PSRKMHKIT-----------PVKEEESSQKMS------KSKE 177

Human   263 -----PKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSA 322
                 ||.|..:...:..::||...|.|     |||:.:..:.:.|..::|    |...:||...
 Worm   178 KGVPIPKIDIEIEKASPKKEKKEKVKSP-----EELTRRLNECTDSHVIYK----ASEYLLTLPD 233

Human   323 DKKQIKDKSHVKMGKVKIESETSEKKKSTL 352
            .|        :....:|:..:.|....:||
 Worm   234 TK--------LSQTTLKLSFDLSRCDSTTL 255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MLLT3NP_004520.2 YEATS_AF-9_like 9..137 CDD:341125 38/133 (29%)
Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM 78..80 0/1 (0%)
Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM 106..108 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..475 40/220 (18%)
Nuclear localization signal. /evidence=ECO:0000255 295..300 0/4 (0%)
AHD 503..563 CDD:436050
Y105E8B.7NP_493542.2 YEATS_AF-9_like 4..133 CDD:341125 38/133 (29%)
Blue background indicates that the domain is not in the aligned region.

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