Protein Alignment ACHE and CG10175

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 195/635 - (30%)
• Similarity: 280/635 - (44%)
• Gaps: 142/635 - (22%)

Human   101 REDAELLVTVRGGRLRG----IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDAT 161
            |::.|::.|...|::||    .|....||..| |.|:.:..||.|.|||...||::||||:.||:
  Fly   149 RKEREIVATTSLGKVRGRYQKYRSGERGGYYS-FKGMRYGAPPTGARRFRAAEPEKPWSGIRDAS 212

Human   162 TFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVW-TPYPRPTSPT-----PVLVWIYGGG 220
            .....| .:.:.:...|:|          .||||::||: |..|:.....     ||:||::|||
  Fly   213 REGQSC-PHKNMILDTFKG----------DEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGG 266

Human   221 FYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENV 285
            |..|:.:..:|...:|| ||..|||::|||:|..|||.  ...:||||.||.||.|||:||::|:
  Fly   267 FSFGSGNSFLYGPDYLV-AEDIVLVTLNYRLGPLGFLT--AGPDAPGNQGLKDQVLALKWVRDNI 328

Human   286 AAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLA 350
            |||||||..||:|||||||:||.:.|||..::||||||:.|||:...|| ::....::|.|...|
  Fly   329 AAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPW-SMSASSSQRAARLAA 392

Human   351 HLVGCPPGGTGGNDTE-LVACLRTRPAQVLVNHEWHVLP-------QESVFRFSFVPVVDG---- 403
            :|     |..|.|.|| ::..||..||..||    ...|       |.:.....|||||:|
  Fly   393 NL-----GYVGANKTEDILDFLRRVPAMKLV----EAAPTTITAEDQRNNIGLPFVPVVEGYWNQ 448

Human   404 ----------DFLSDTPEALINAGDFHG-LQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAE- 456
                      .||:..|..:.::.:|:. :..:.|....|...|:     ...:.|..|:|..|
  Fly   449 DSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFI-----RRLRKNPQLLSIIEN 508

Human   457 ---FLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 518
               .|....:.|.:..|.....:...|....|              ||..:|...:|.|...:..
  Fly   509 DFGRLVPQDLNVTESHDRVTREIRSFYLGSKH--------------VGIESVDEMIALLTDLMFL 559

Human   519 QGAR-------------VYAYVFEHRASTLSWPLWMGVP-----HGYEIEFI-----FGIPLDPS 560
            ||.|             ||.|.|....|...:...:|:|     ||.|:.::     |.:.|||.
  Fly   560 QGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPK 624

Human   561 RNYTAEEKIFAQRLMRYWANFARTGDPN-EPRDPK-APQWPPYTAGAQQYVSLDLRPLEVRRGLR 623
                :.|.....|::|.|.|||:.|.|. :..||. ..:|.|            :.|..|...|
  Fly   625 ----SMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAP------------IDPTNVMNSL- 672

Human   624 AQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYS 673
                   |........|..|..|.|||      |:      |...:.||:
  Fly   673 -------NYMDISANLAMKTNPEPERQ------RF------WDEMYQHYN 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	183/587 (31%)
		AChE_tetra	645..678	CDD:430146	8/29 (28%)
CG10175	NP_001287487.1	COesterase	155..695	CDD:395084	190/619 (31%)