Protein Alignment ACHE and CG4757

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_650043.1
• Gene: CG4757 / 41330
• FlyBaseID: FBgn0027584
• Length: 550
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 200/610 - (32%)
• Similarity: 292/610 - (47%)
• Gaps: 133/610 - (21%)

Human    84 LLLL----LLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTP-GGPVSAFLGIPFAEPPMGPR 143
            :|:|    ||.||..........|.||      ||:||..|.:. |....||.||.:||||:|..
  Fly     1 MLMLFVVELLVLLASSSVLSIEVDTEL------GRVRGANLTSRLGVNFHAFRGIRYAEPPLGDL 59

Human   144 RFLPPEPKQPWS-GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT 207
            ||:.|:|.:||| .:.||:....:|.|             .|:...::|||||.|||:|...:
  Fly    60 RFVNPQPVKPWSPKIFDASEDGPMCPQ-------------PWDNMTDVSEDCLRLNVYTKDLK-- 109

Human   208 SPTPVLVWIYGGGFYSGASSLDVYDG--RFLVQAER-----TVLVSMNYRVGAFGFLALPGSREA 265
            ...||:|:::.||||       |:.|  ::|...|.     .||||:|||:|:.|||| .||:||
  Fly   110 GRRPVIVFLHPGGFY-------VFSGQSKYLAGPEHFMDRDCVLVSLNYRLGSLGFLA-TGSKEA 166

Human   266 PGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAP 330
            |||.||.||.|||:|:|:::..|||||.||||.|.|||:.||.:|:|||.|||||||.:..|.||
  Fly   167 PGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSAAP 231

Human   331 NGP--WATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVF 393
            .||  :....:..|:|:    |.|:.||....|    |:|.|:|.:|      :..:|.....:|
  Fly   232 YGPVKYKDNDLQLAKRQ----AGLLKCPQESIG----EMVECMRRKP------YLDYVSTYNGMF 282

Human   394 RFSFVP------VVDGDF-----LSDTPEALINAGDFHGLQVLVGVVKDE---GSYFLVYGAPGF 444
            .|.:.|      ||:.||     |.::|......||||.:.::.|:.:.|   |::        |
  Fly   283 EFGWNPVLNWRIVVEKDFGQERYLIESPFKTARRGDFHKVALITGITEFEFLSGAF--------F 339

Human   445 SKDNESLISRA----EFLAGVRVGVPQVSDLAAEAVVLHYTDWL--------HPEDPARLREALS 497
            ...|||:::|.    |..|.:.:.:.|.|..:..|..:....::        :|:....:.|.||
  Fly   340 DLRNESIVNRYNRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLS 404

Human   498 DV---VGDHNVVCPVAQLAGRLAAQGARVYAYVFEH--RASTLSWP---LWMGVPHGYEIEFIFG 554
            |.   |..|..:        :|.:....:|.|:|.:  |.:.|..|   ..:|..|..|:.::|.
  Fly   405 DALIGVSFHRFL--------QLMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFH 461

Human   555 ----IPL----DPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDP--KAPQWPPYTAGAQQYV 609
                |||    ||       |....:.|.|.|..||:.|||:...|.  |...||.|.|..:.|
  Fly   462 VGLLIPLLKREDP-------ENFMIELLTRMWIEFAQKGDPHNKNDEYLKGLNWPLYNAQDKGY- 518

Human   610 SLDLRPLEVRRGLRAQACAFW-NRF 633
                  ||:...|.|::..|: ||:
  Fly   519 ------LEIGNNLTAKSGGFFLNRY 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	190/580 (33%)
		AChE_tetra	645..678	CDD:430146
CG4757	NP_650043.1	COesterase	20..540	CDD:395084	194/591 (33%)