Protein Alignment ACHE and alpha-Est2

DIOPT Version :9

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_001262345.1
• Gene: alpha-Est2 / 40908
• FlyBaseID: FBgn0015570
• Length: 566
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 172/600 - (28%)
• Similarity: 277/600 - (46%)
• Gaps: 139/600 - (23%)

Human   106 LLVTVRGGRLRGIRLKT--PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCY 168
            :::..:.|::||::.||  ...|..||.|||:|:||:|..||..|:|.:||.||::.||.:|...
  Fly    33 VILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTTNRSKPM 97

Human   169 QYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDG 233
            |. :.|....||          |||||:|||:....:...|.||:||||||||..|.:|.|:|..
  Fly    98 QR-NMLLGIVEG----------SEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKGEASRDIYSP 151

Human   234 RFLVQAERTVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL 297
            .:.:: :..|.|::|||:.|.|||:|...: :.|||.||.||.:||:|:.:|:|.|.|||.::||
  Fly   152 DYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFNGDPNNITL 215

Human   298 FGESAGAASVGMHLLSPPSRGLFHRAVLQSG--------APNGPWATVGMGEARRRATQLAHLVG 354
            .|||||:|||.:.:.:..:|||||:|::|||        :|:..||.       |.|..|
  Fly   216 MGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAF-------RLAQNL----- 268

Human   355 CPPGGTGGN--DTELVACLRTRPAQVLVNHEWHVLPQESV---FRFSFVPVVD------------ 402
                |..|:  |.::::.|....|:.:...:..|:..:.|   ..|:|.||::
  Fly   269 ----GYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKR 329

Human   403 -GDFLS-----DTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGV 461
             .|.||     |.| .::....|.||          .||.||...|...|:..:::.|.
  Fly   330 HKDLLSEAWGNDIP-VIVGGNSFEGL----------FSYQLVRKDPWALKNFHNILPRE------ 377

Human   462 RVGVPQVSDLAAEAVVLHYTDWLH----PEDPARLREALSDVVGDHNVVCPVAQ---LAGRLAAQ 519
               |.:.|.|..:.:::.....|:    .::...:.|||:  :..|..:.....   ||.:..|.
  Fly   378 ---VRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALN--IFSHRQIWHDTHRFILARQSYAP 437

Human   520 GARVYAYVFEHRASTLSWPLW------------MGVPHGYEIEFIF----GIPLDPSRNYTAEEK 568
            ....|.|.|:..:     |.:            .||.|..|:.::|    ...||.|   :.|.|
  Fly   438 KTPTYLYRFDFDS-----PHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKS---SMEYK 494

Human   569 IFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLR------------PLEVRRG 621
            .. :|::..|.:||.:|:||.|.           .|:.::.::.|:            .||:|..
  Fly   495 TI-ERMVGMWTSFASSGNPNCPE-----------LGSAKWEAVQLKENAVEKCFNISHDLEMRDL 547

Human   622 LRAQACAFWNRFLPK 636
            ..:...|.|:.|.|:
  Fly   548 PESDCLAVWDTFYPR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	169/592 (29%)
		AChE_tetra	645..678	CDD:400834
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	164/559 (29%)
		Aes	<117..>221	CDD:223730	47/104 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4180
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.690