Protein Alignment ACHE and alpha-Est4

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_524266.1
• Gene: alpha-Est4 / 40906
• FlyBaseID: FBgn0015572
• Length: 541
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 167/550 - (30%)
• Similarity: 244/550 - (44%)
• Gaps: 90/550 - (16%)

Human   102 EDAELLVTVRGGRLRGIRLKT-PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQS 165
            |||.::.|.. |::|||.||: ......||.|||:|.||:|..||..|...:||.|:.|.:...|
  Fly     7 EDAPVVQTTH-GKVRGILLKSLYDEQFYAFDGIPYAVPPLGTLRFKEPHDLKPWHGIRDCSKPLS 70

Human   166 VCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDV 230
            .|.| |.||....||          ||||||||: :.......|.||:|:|:||.|..|.||...
  Fly    71 KCLQ-VSTLTKEVEG----------SEDCLYLNI-SVKTLNGDPMPVMVYIHGGAFKGGDSSRRA 123

Human   231 YDGRFLVQAERTVLVSMNYRVGAFGFLAL-PGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTS 294
            :...:.:: |..|.:|:.:|:|..|||:| ....|.|||.||.|..|||:|::.|.|.|.|||..
  Fly   124 WGPDYFMK-ENVVYISIGHRLGPLGFLSLNDPDLEVPGNAGLKDVILALRWIRANAANFNGDPER 187

Human   295 VTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGG 359
            :|:||.|:|:.:|.:.|.||.|.||||||:|          ..|......|..|:.:.:....|.
  Fly   188 ITIFGHSSGSMTVQLLLASPQSEGLFHRAIL----------LAGFSMELNRLPQMEYRLAKHLGY 242

Human   360 TGGN-DTELVA-CLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDF--- 419
            .|.| |::::. .|:..||.::....:..|.:.......|.|.::.   ..||.|::.|...
  Fly   243 EGDNVDSQVLEFLLKADPALIVSADFFTPLEKRQGHNMPFKPSIES---YSTPNAVLLAEPIDLQ 304

Human   420 -----HGLQVLVGVVKDEG-SYFLVYGAPGFSKDNESLISRAEFLAGVRVGVP----------QV 468
                 :.:.:::|....|| |.|      .|.|.|.|.:.  ||.......:|          |.
  Fly   305 RTTWSNRIPIILGANSGEGMSIF------SFVKMNPSWLK--EFQCNPERVLPWTLRNRCDPGQR 361

Human   469 SDLAAEAVVLHYTDWLHPEDPARLREALSDVVG------DHNVVCPVAQL-AGRLAAQGARVYAY 526
            ..| .:|::.|:.:       |...|...|...      .|..|..:.:| ..||....|..|.|
  Fly   362 RQL-GQALIHHFCE-------AHGHELTVDHTNGLVELFTHGFVHAMDRLIQSRLTYGQAPTYLY 418

Human   527 VFEHRASTLSW-------PLWMGVPHGYEIEFIFGIP----LDPSR-NYTAEEKIFAQRLMRYWA 579
            .|:..:...::       ....||.|..|:.:||.:|    ||.|| .:||     .:||:..:.
  Fly   419 RFDFDSPDFNFYRIRFMGKEQRGVGHVDELGYIFKLPATFKLDKSRPEFTA-----IRRLVAMFV 478

Human   580 NFARTGDPNEPRDPKAPQWPPYTAGAQQYV 609
            .||.|.|||.|.......|.|.|...::.|
  Fly   479 QFAATSDPNAPLTKSLVDWKPVTRFGKRMV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	164/547 (30%)
		AChE_tetra	645..678	CDD:430146
alpha-Est4	NP_524266.1	alpha/beta hydrolases	8..529	CDD:473884	165/548 (30%)