Protein Alignment ACHE and alpha-Est9

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 577
• Identity: 169/577 - (29%)
• Similarity: 270/577 - (46%)
• Gaps: 94/577 - (16%)

Human   101 REDAELLVTVRGGRLRGIRLKT-PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTF- 163
            |...:.:|:...|.::|::.|: .|....:|..||||:||:|..|:..|:|.:.|:.|...|:.
  Fly    27 RTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91

Human   164 -QSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASS 227
             :.:...:|      ||.|:.       |||||||||:|....||.|.||:||||||||..|.:|
  Fly    92 PKPLQKHFV------FEMTDG-------SEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEAS 143

Human   228 LDVYDGRFLVQAERTVLVSMNYRVGAFGF------------LALPG-------SREAPGNVGLLD 273
            .:.|...:|:: |..|::|:|||:|..|.            ::|||       ..:.|||.||.|
  Fly   144 RECYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKD 207

Human   274 QRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA-TV 337
            |.|||:||:.|.:.||||..::|:||:|||:|||...:::..:.||||:|:..||....||| |.
  Fly   208 QVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTP 272

Human   338 GMGEARRRATQLAHLVGCPPGGTGGNDT-ELVACLRTRPAQVLVNHEWHV-LPQESVFR--FSFV 398
            ......|.|.|        .|..|.|:| ::...|:......::.....: :.:|...|  |||.
  Fly   273 QRNWPYRLAVQ--------AGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFG 329

Human   399 PVVDGDFLS-----DTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAE-- 456
            ||::....|     ..|..::.....:.:.:::|.|.:||  .|:|..   :|.|...::..:
  Fly   330 PVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEG--LLLYSE---TKTNPKCLNELDDC 389

Human   457 -FLAGVRVGVPQVSDLAAEAVVLHYTDWLH-----PEDPA--RLREALSDVVGDHNVVCPVAQLA 513
             |:..:.:.:.:.|.|..|     |.|.|.     .:.|:  .|.|.|..|..::........:.
  Fly   390 RFVVPIELNMDRESALCRE-----YGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVL 449

Human   514 GRLA-AQGARVYAYVFE-------HRASTLSWPLWMGVPHGYEIEFIFGIPLDPS-RNYTAEEKI 569
            .||. |:.|..|.|.|:       |...........|..||.::.::|...|... :|:|.|.|.
  Fly   450 SRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKC 514

Human   570 FAQRLMRYWANFARTGDPNEPRDPKAPQ-WPPYTAGAQQ-------YVSLDLRPLEV 618
            . :||:..|.:||..|:||  .||:... |.|....|.:       .:|.:|:.::|
  Fly   515 I-ERLVGLWTHFAACGNPN--FDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	168/574 (29%)
		AChE_tetra	645..678	CDD:430146
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	168/572 (29%)