Protein Alignment ACHE and Est-Q

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 177/620 - (28%)
• Similarity: 271/620 - (43%)
• Gaps: 131/620 - (21%)

Human    80 LASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV--------------SAF 130
            |.:.|...|:..|.||.||:..|.|.:.|.:..|:          |.|              ..|
  Fly    16 LTAGLTAFLVIFLTGGQGADASETATVTVELYNGQ----------GTVLGNYAYTAWTDRAFMQF 70

Human   131 LGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCL 195
            .||||||||:...||.||..:.||:|.::|..|...|        |.....:....:.|| ||||
  Fly    71 RGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRC--------PVITNLDSQMSDAEL-EDCL 126

Human   196 YLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALP 260
            .|:|:|  ...::..||:.:|||||||:|:|  :.:...:|::.: .|||...|||||.|:|: .
  Fly   127 TLSVYT--KNLSASQPVMFYIYGGGFYNGSS--EDHPPNYLLEKD-VVLVVPQYRVGALGWLS-T 185

Human   261 GSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPS-RGLFHRAV 324
            .:.|.|||..:.|..:||.|||.::::|||||..||:||:||||......||||.: ..:|.||:
  Fly   186 YTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAI 250

Human   325 LQSGAPNGPWA--TVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL 387
            :|||:....||  .....::||...||    ||  .|...:| :||.|:  :.|:|:     .:|
  Fly   251 VQSGSIFASWAINKDPKAQSRRICIQL----GC--SGCEQHD-QLVKCI--QKAKVI-----DIL 301

Human   388 PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHG----------------LQVLVGVVKDEGSYF 436
              ::....||.|:|               ||.||                :.:|.|..:.:||:.
  Fly   302 --KATASESFSPIV---------------GDLHGILPQQPSELVKSYRRQIPILTGFTQHDGSFV 349

Human   437 LV--YGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAV--VLHYTDWLHPEDPARLREALS 497
            |.  |.|......|.|.:|..:|..|:...|...|.|....:  :|.....|:..|.:....:..
  Fly   350 LASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYF 414

Human   498 DVVGDHNVVCPVAQLAGRLAAQ--GARVYAYVFEHRAS---------TLSWPLWMGVPHGYEIEF 551
            |:..:..:..||..||.::..|  ...||.|.||:..:         ...:|...||.|..:..:
  Fly   415 DLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIY 479

Human   552 IFGI-PLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRP 615
            :|.. ||:      .::...:|:::..|.:||..|.|.        ...|.::.:..|..|:
  Fly   480 LFATHPLE------GQDTQMSQKMVDVWTSFAIEGVPR--------NLSPLSSASGPYNKLN--- 527

Human   616 LEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQ 650
            |||.:|         :..|..|.:|.|..|....|
  Fly   528 LEVTKG---------DDLLDTLTAAIDDPDNGRLQ 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	162/574 (28%)
		AChE_tetra	645..678	CDD:430146	2/6 (33%)
Est-Q	NP_649321.1	COesterase	50..536	CDD:395084	159/567 (28%)