Protein Alignment ACHE and Nrt

DIOPT Version :9

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_001189121.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 154/626 - (24%)
• Similarity: 219/626 - (34%)
• Gaps: 204/626 - (32%)

Human    86 LLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVS--------AFLGIPFAEPPMGP 142
            :||..||.|.:|.....:......:|.||.  |...|..|||.        ||.|||:|:||:..
  Fly   331 ILLFVLLLGVIGYVLTHETLTSPPLREGRY--IMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDR 393

Human   143 RRFLPPE----PKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPY 203
            .|:.|.|    ....|:..:.......||.|.:.      .||.:.:      ||||||:|.||:
  Fly   394 LRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLG------NGTTVGD------EDCLYLDVVTPH 446

Human   204 PRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAER------TVLVSMNYRVGAFGFLALPG- 261
            .|..:|.||:|.|       ||.||.......|..:.|      .:.|..|:|:|.||||||..
  Fly   447 VRYNNPLPVVVLI-------GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDAL 504

Human   262 SREA----PGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHR 322
            ::||    .||..|.|....|.|::.|:..|||||.||||.|..|||..|.:.:.|...:||:.|
  Fly   505 TKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTR 569

Human   323 AVLQSGA---PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVL----- 379
            |...||:   |..|     :.|:.::..||...:.|..          :.|||...::.|
  Fly   570 AWASSGSAILPGKP-----LSESGKQNEQLMATLECAD----------IQCLREASSERLWAATP 619

Human   380 --------------------VNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQV 424
                                ..|||.||              |||.:.:.|.........:...|
  Fly   620 DTWLHFPVDLPQPQEANASGSRHEWLVL--------------DGDVVFEHPSDTWKREQANDKPV 670

Human   425 LVGVVKDEGSYFLVYGAPGFSKDNESL------ISRAE---FLAGVRVGVPQVSDLAAEAVVLHY 480
                        ||.||.......|.|      .:|.|   :|...::|...::|    .|:..|
  Fly   671 ------------LVMGATAHEAHTEKLRELHANWTREEVRAYLENSQIGALGLTD----EVIEKY 719

Human   481 TDWLHPEDPARLREALSDVVGDHNVVCP---------------VAQLAG--RLAAQGARVYAYVF 528
            .        |....:|..::.|...|||               |.|..|  :||...|.|.|.:.
  Fly   720 N--------ASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILG 776

Human   529 EHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFA---QRLMRYWANFA-------- 582
            .:.            ||                  |.|::.|.   |:|..|:.:..
  Fly   777 RYE------------PH------------------TVEQRRFVSAMQQLFYYYVSHGTVQSFVQN 811

Human   583 ----RTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVR 619
                ..|...:|.:...|        ...::|.|:.|...|
  Fly   812 RRVINVGQDAQPEEDYLP--------CNYWISKDIVPRYAR 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	148/608 (24%)
		AChE_tetra	645..678	CDD:400834
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	140/579 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010