DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACHE and Jhe

DIOPT Version :10

Sequence 1:NP_001354847.1 Gene:ACHE / 43 HGNCID:108 Length:681 Species:Homo sapiens
Sequence 2:NP_523758.3 Gene:Jhe / 36780 FlyBaseID:FBgn0010052 Length:579 Species:Drosophila melanogaster


Alignment Length:581 Identity:174/581 - (29%)
Similarity:246/581 - (42%) Gaps:146/581 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    86 LLLLWLLGGGVGAEGREDAELLVT------------VRGGRLRGIRLKTPGGPVSAFLGIPFAEP 138
            :|.|.|||..:...|...|.|...            ::|..|:|.:.:.    ..||:|||:|.|
  Fly     6 MLQLLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSER----FEAFMGIPYALP 66

Human   139 PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPY 203
            |:|..||..|:......|:.||:..:..|.| .:.|.|        .|.....||||||||:.|.
  Fly    67 PIGDLRFSNPKVMPKLLGMYDASAPKMDCIQ-KNYLLP--------TPVVYGDEDCLYLNVYRPE 122

Human   204 PRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREA--P 266
            .| .|..||:|:|:||||:.|::...|....:.:.:...:||:|.||:|.||||:   :::|  .
  Fly   123 IR-KSALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLS---TQDAVMS 183

Human   267 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPN 331
            ||.||.||.|||:|||.|:..|||||..||:||:|||..:..||||||.|.|||||.:..||..|
  Fly   184 GNFGLKDQNLALRWVQRNIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTAN 248

Human   332 GPWATVGMG-EARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVN-----HEWHVLPQE 390
            .|:|..... |..|...:.|.:    |.....:..:|...||...|..|:|     ..|.|    
  Fly   249 VPFAIAEQPLEQARLLAEFADV----PDARNLSTVKLTKALRRINATKLLNAGDGLKYWDV---- 305

Human   391 SVFRFSFVPVVD-----GDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLV--YGAPGFSKDN 448
             ....:|.|||:     ..||:..|..::..|....:.:|:|.|..||:..:|  .|       |
  Fly   306 -DHMTNFRPVVEEGLEVDAFLNAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILG-------N 362

Human   449 ESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARL----REALSDVV------GDH 503
            |:|  |..|..       :..:|..|.:          |.||..    ||.:.|::      |.|
  Fly   363 ETL--RQSFNL-------RFDELLQELL----------EFPASFSQDRREKMMDLLVEVYFQGQH 408

Human   504 NVVCPVAQLAGRLAAQGAR--------------------------VYAYVFEHRASTLSWPL--- 539
            .|        ..|..||..                          ||.|.|.::.     ||   
  Fly   409 EV--------NELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYSFNYQG-----PLSYA 460

Human   540 ----------WMGVPHGYEIEFIFGIPL---DPSRNYTAEEKIFAQRLMRYWANFARTGDP 587
                      ..||.|..::.::|..||   |..||.| |.|:. ...:.|:.:||:.|.|
  Fly   461 SAYTSANVTGKYGVVHCDDLLYLFRSPLLFPDFQRNST-EAKVI-HSFVDYFVHFAKFGKP 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACHENP_001354847.1 COesterase 104..630 CDD:395084 168/563 (30%)
AChE_tetra 645..678 CDD:430146
JheNP_523758.3 alpha/beta hydrolases 38..527 CDD:473884 166/549 (30%)
Blue background indicates that the domain is not in the aligned region.

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