Protein Alignment ACHE and CG12869

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 159/613 - (25%)
• Similarity: 249/613 - (40%)
• Gaps: 166/613 - (27%)

Human   108 VTVRGGRLRGIRLKTPG--GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQY 170
            :.:..|.|.|:::...|  |.|.||||||:|:.|:...||.|.:|...::..:.|||.|.:|.|.
  Fly    31 IKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQL 95

Human   171 VDTLYPGFEGTEMWNPNRELS--EDCLYLNVWTP-----YPRPTSPTPVLVWIYGGGF-----YS 223
            .:|:|.  |.::...| |.:|  |||||||:|||     |.:    .|::|.:.|..|     .:
  Fly    96 ANTIYD--ESSDGSMP-RSVSTDEDCLYLNIWTPESGMRYGK----LPIVVIVTGEEFAYDWPRN 153

Human   224 GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLAL-PGSREAPGNVGLLDQRLALQWVQENVAA 287
            ..:.||       :..|..|:||:.||...:|:|:| ...|..|||.||.|.::||:|::.|..|
  Fly   154 RINGLD-------LAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADA 211

Human   288 FGGDPTSVTLFGESAGAASVG-------------MHLLSPPSRGLFHRAVLQSGAPNGPWATVGM 339
            |||:|..:||.|..:|.|.:.             :.|:||   |...||:   |..:..| .|..
  Fly   212 FGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSP---GPIMRAL---GQNHQKW-IVET 269

Human   340 GEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLV-------NH-----EWHV-----L 387
            |:.      |...:||.  .......:|:.|||.:..:.|:       ||     :..|     |
  Fly   270 GQV------LVQKLGCQ--FEEAQRRQLMGCLRRKSREDLLRAYESVYNHGNGSSQLGVILPEGL 326

Human   388 PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVY-------GAPGFS 445
            |.|...|...:|                       .||:|:..:||::...|       |.....
  Fly   327 PLEQRLRNKTLP-----------------------PVLLGITSNEGAFLQDYWLDVAREGQVALH 368

Human   446 K-DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLH----PEDPARLREALSDVVGDHNV 505
            | .|.:|:... ..|...||....:.|||       ..|.:    .|..:.|...:..::.:...
  Fly   369 KYINHTLLPNV-MRALESVGEESSTQLAA-------IRWRYFNGKGEGVSHLLAGMQRLLSESLY 425

Human   506 VCPVAQLAGRLAAQGARVYAYVFEH--------RASTLSWPLWMGVPHGYEIEFIFGIPLDPS-- 560
            ..|.:::...|  .|...|||||:|        |.:     |:.|..|..::..:.|    ||
  Fly   426 ELPYSRILELL--NGTTSYAYVFDHSHSMDMRGRRN-----LFGGASHSSDLPLLLG----PSLF 479

Human   561 -----RNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRR 620
                 |.::.||:...:::...:|||.:.|:|...|....  |.||...         .|.....
  Fly   480 QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPTPGRIYDG--WLPYNKE---------NPFVYSL 533

Human   621 GLRAQACAFWNRFLPKLLSATDTLDEAE 648
            |.:|:.        |:    |.::||||
  Fly   534 GEQAKT--------PQ----TGSVDEAE 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	153/593 (26%)
		AChE_tetra	645..678	CDD:430146	4/4 (100%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	153/599 (26%)