Protein Alignment ACHE and CG9289

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_609245.1
• Gene: CG9289 / 34195
• FlyBaseID: FBgn0032058
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 187/732 - (25%)
• Similarity: 286/732 - (39%)
• Gaps: 207/732 - (28%)

Human    25 QHRPTRGGSRSFHCRRGVRPRPAALRVLPRCPAFSADAACPAAMRPPQCLLHTPSLASPLLLLLL 89
            |.:| |.|:::|..::..||:|..::                ..:|.:
  Fly    34 QQKP-RPGNQNFGIQKNKRPKPQKVQ----------------KQKPNK----------------- 64

Human    90 WLLGGGVGAEGREDAELLVTVRG-GRLRGIRLKT--PGGPVSAFLGIPFAEPPMGPRRFLPPEPK 151
                 ..|..|:|......||.. |||||..|.|  .|..:..||.||:.:    ..||.|.||.
  Fly    65 -----QQGQNGQEPKVFTTTVPDLGRLRGRTLTTDWTGQKIMQFLDIPYGK----AERFRPAEPA 120

Human   152 QPWSGVVDATTFQSVCYQYVDTLY------PGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPT 210
            ..|.||:.|....:.|....|.:.      .||:           .||||.|:|.|......| .
  Fly   121 PSWKGVLPAHRPHAGCPSIQDLIVFAKLEEDGFD-----------VEDCLRLSVNTKAMEGKS-L 173

Human   211 PVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQR 275
            ||:|:|:|..||.| .|::...| :|::.: .||||:.||:|.||||:.. :.|.|||..:.|..
  Fly   174 PVMVYIHGDFFYDG-DSVEAAPG-YLLEHD-VVLVSVRYRLGPFGFLSTL-TDEMPGNAAVTDII 234

Human   276 LALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSP--PSRGLFHRAVLQSG---------- 328
            |||:|||:::|:|||||..|||||:..|||.|.:..|||  |: |||||.:.|||
  Fly   235 LALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPAVPA-GLFHRVIYQSGTALSPAFITD 298

Human   329 APNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACL-RTRPAQVLVNHEWHVLPQESV 392
            ||.|....:|.....:::|::               .:|..|| |.....:|.....|...|.|:
  Fly   299 APLGATKAIGRIAGCKQSTKV---------------DQLNKCLNRLNATMLLAAFSVHGENQPSL 348

Human   393 F--RFSFVPVVDG---DFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLI 452
            .  .:..|.:|.|   ..|.:.|..|:.|..|.....:.|.||..|::.|        :|..:.|
  Fly   349 SGGAYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFML--------RDIFADI 405

Human   453 SRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPA-----------------------RLRE 494
            .....|.....|...:..:..:|         :..||:                       ||..
  Fly   406 FNETILDDTMTGRQYIDTIIEQA---------NGADPSGSWKEFSDEEIFTQNDVKNGTFKRLTP 461

Human   495 ALSDVVGDHNVVCPVAQLAGRLAAQGARV----YAYVFEHRASTLSW----------PLWMGVPH 545
            .|.|:....::..||..:   |.|...::    |.|.|::......:          |..|||..
  Fly   462 GLIDLCSTISLKNPVLLV---LQANAKKLPNSTYLYSFDYEGEQNRYATGEDEANFVPFDMGVSL 523

Human   546 GYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVS 610
            ..:..::|..|...:.|...:.|: |:|::..|.:||.||   .|:.|..|.||........|:.
  Fly   524 TDDNLYLFPWPRFLALNSNRDLKV-ARRMVALWTSFATTG---VPQAPGLPAWPAMNDETGPYMK 584

Human   611 LDLRPLEVRRGLRAQACAFWNRFLPK-------------------------LLSAT--DTLDEA- 647
            :|            :..:|.:.:|.:                         ||:|:  |:|::|
  Fly   585 ID------------RTVSFGDNYLDEYRIAVEEAKHGYNLVNDEYYDLQEALLAASKLDSLNDAN 637

Human   648 ----ERQWKAEFHRWSS 660
                |.|..||..|.:|
  Fly   638 EEDEEDQDDAEGQRAAS 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	161/589 (27%)
		AChE_tetra	645..678	CDD:430146	7/21 (33%)
CG9289	NP_609245.1	COesterase	71..598	CDD:395084	164/598 (27%)