Protein Alignment ACHE and Glt

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 151/528 - (28%)
• Similarity: 221/528 - (41%)
• Gaps: 103/528 - (19%)

Human   126 PVSAFLGIPFAEPPMGPRRFLPPEPKQP--WSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR 188
            ||:|||||.:.....|..||   :..||  :.|.|:||.....|.|     :|..:...:.....
  Fly    83 PVNAFLGIRYGTVGGGLARF---QAAQPIGYQGRVNATVQSPNCAQ-----FPELDRLRLSESRG 139

Human   189 ELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGA 253
            |..:|||.|:::.  |...:..||||:::|...:.|.|.....|   .|..:..:|||:|||:..
  Fly   140 ENVDDCLTLDIYA--PEGANQLPVLVFVHGEMLFDGGSEEAQPD---YVLEKDVLLVSINYRLAP 199

Human   254 FGFL-ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 317
            |||| ||  :.|.||||.|.|.:|||:|:|.||..|||:...|||.|::.||.......||..:.
  Fly   200 FGFLSAL--TDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAG 262

Human   318 GLFHRAVLQSGA-------PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGND---TELVACLR 372
            .||.:.:||||.       .|.|..|:         :..|.|..|||.....:.   ..|..||.
  Fly   263 NLFQQLILQSGTALNPYLIDNQPLDTL---------STFARLARCPPPSINPSAQGLKPLYDCLA 318

Human   373 TRPA--------QVLVNHEWHVLPQESVFRFSFVPVVDGD---FLSDTPEALINAGDFHGLQVLV 426
            ..|.        |:|:.:|...|.|...|:     :|.||   ||...|.:|...... .|.:::
  Fly   319 RLPTSQLVAAFEQLLLQNEHLGLTQLGGFK-----LVVGDPLGFLPSHPASLATNSSL-ALPMII 377

Human   427 GVVKDEGSYFLVYGAPGFSKDNESLISRA-EFLAGVRVGVPQVSDLAAEAVVLHYT--------- 481
            |..||..::               ::||. :.||  |:....|||..  .|||.:|
  Fly   378 GATKDASAF---------------IVSRIYDQLA--RLQSRNVSDYI--DVVLRHTAPPSEHRLW 423

Human   482 -DW-----LHP--EDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVF-------EHR 531
             .|     ..|  |..|.|:.....::...|.:...|.:...::.....|.||::       .||
  Fly   424 KQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHR 488

Human   532 ASTLSWPLWMGVPHGYEIEFIFGIPLDP-SRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKA 595
            ...||.||..||......:.::..|..| :......::..::.|:..|.|||.||.||    |.:
  Fly   489 FGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPN----PSS 549

Human   596 PQWPPYTA 603
            ..||..|:
  Fly   550 GVWPQATS 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	151/528 (29%)
		AChE_tetra	645..678	CDD:430146
Glt	NP_477504.1	COesterase	58..579	CDD:395084	151/528 (29%)
		Casc1_N	681..>717	CDD:464947