Protein Alignment ACHE and Nlg2

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 190/627 - (30%)
• Similarity: 264/627 - (42%)
• Gaps: 148/627 - (23%)

Human    57 AFSADAACPA-AMRPPQCLLHTP--SLASP-----------LLLLLLW-----LLGGGVGAEGRE 102
            |.||.:|.|| |..|.:..||.|  |...|           |||..||     .|.||...
  Fly   124 ATSAASAAPAGATSPRRRHLHYPGHSAVQPGHPEACALLVLLLLTSLWPDCCECLHGGSNT---- 184

Human   103 DAELLVTVRGGRLRGIRLKTPGGP-VSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSV 166
                 |..:.|.||||.:::  .| |.||||||:|.||:|..||:||.....|..|..|..|..|
  Fly   185 -----VKTKYGLLRGIVVRS--SPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242

Human   167 CYQYVDTLYPGFEGTEMWNPNREL-------------SEDCLYLNVWTPYP-------------R 205
            |.|.: .:.|......:..|...|             ||||||||::.||.             .
  Fly   243 CPQNI-PIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYETRRQRRNTDDTTGE 306

Human   206 PTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVG 270
            |.:....:|:|:|..:  ..:|.:.|||..|......::|::|:|:|.||||...|...|.||.|
  Fly   307 PKTKLSTVVFIHGESY--DWNSGNPYDGSELAAHGNVIVVTINFRLGIFGFLKTGGKESAQGNFG 369

Human   271 LLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA 335
            |:|....|.|::||:.||||||.|:||.|...||....:.::||.:..|..|.||.||:...|||
  Fly   370 LMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLANILVVSPVASDLIQRTVLVSGSALSPWA 434

Human   336 TV--GMGEARRRATQLAHLVGCPPGGTGGND---TELVACLRTRP-AQVL---VNHEWHVLPQES 391
            ..  .:...||.|.|    .||      ..|   .:|..||||:. |::|   |:|     |:
  Fly   435 IQKNPLFVKRRVAEQ----TGC------HGDMLYDDLAPCLRTKSVAELLAVKVDH-----PR-- 482

Human   392 VFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAE 456
             |...|.|.|||..:|.....|                   ||..|..|:...|   .|.|..|.
  Fly   483 -FLVGFAPFVDGTVISPGANPL-------------------GSTTLPLGSAIVS---TSGIEYAN 524

Human   457 F----LAGVRVGVPQVSDLAAE-------------------------------AVVLH-YTDWLH 485
            |    |......|....||:|:                               ||:.: ||||..
  Fly   525 FPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRNNFHYHLNEIFAVLKNEYTDWEK 589

Human   486 P-EDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEI 549
            . .:|...|:|....:.|.:...|:.:|....:.:|.|.|...|:|:.....:|...|...|.::
  Fly   590 AIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDV 654

Human   550 EFIFGIPLDP--SRNYTAEEKIFAQRLMRYWANFARTGDPNE 589
            .|..|:|:.|  ..|||.:|:...:.::||.:|||:||:||:
  Fly   655 PFWLGLPMSPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQ 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	169/561 (30%)
		AChE_tetra	645..678	CDD:430146
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	169/569 (30%)