Protein Alignment ACHE and CG6414

DIOPT Version :10

• Sequence 1: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Sequence 2: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 206/619 - (33%)
• Similarity: 288/619 - (46%)
• Gaps: 124/619 - (20%)

Human    84 LLLLLLWLLGGGVGAEGREDAELLVTV-RGGRLRGIRLKTPGG-PVSAFLGIPFAEPPMGPRRFL 146
            |.:.:.|       ::||....|.|.: .||.|.|..|.|..| .:.||:|:|:||||:...||.
  Fly    15 LCICIQW-------SDGRNSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFR 72

Human   147 PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR-----ELSEDCLYLNVWTP-YPR 205
            ||.||.||.|...|.....:|.|.              :|.|     |.|||||||||:|| .||
  Fly    73 PPVPKAPWEGERLAIKDAPICLQR--------------DPFRRDMILEGSEDCLYLNVYTPERPR 123

Human   206 PTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVG 270
            .....||:||.:|||:..|:.....|...||:..: .||||.|:|:|..|||:.. :.:.|||.|
  Fly   124 TNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHD-IVLVSANFRLGPLGFLSTE-TLDCPGNNG 186

Human   271 LLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA 335
            |.||...|.||:.|:|:|||||.|||:||||||.|||..|:||..||||.||.:.|||....|||
  Fly   187 LKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA 251

Human   336 -TVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVP 399
             ....|.|..|||:||.:|||   |..|...|.:.|||.:||:.:|...:.:...:......|.|
  Fly   252 QPAHKGVAAGRATKLAQIVGC---GNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPP 313

Human   400 VV----DGDFLSDTPEALINAGDFHGLQ--VLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFL 458
            ||    ||.||:..|.   .|...||||  ::||...:||   |:..|        :|::..:.|
  Fly   314 VVEPEHDGAFLTVAPR---QAAKPHGLQLPLMVGATAEEG---LLKTA--------ALLNLPQLL 364

Human   459 AGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARL---------------------REALSDVVGD 502
            |..:....||.     .|||:|.   |.:|..|.                     .:.|:|::.|
  Fly   365 AEFKSQFEQVL-----PVVLNYD---HHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISD 421

Human   503 HNVVCPVAQ-LAGRLAAQG-ARVYAYVFEHRASTLSWPL-------WMGVPHGYEIEFIF--GIP 556
            ...|..:.: |..|::.:. |..|.|:|:|:.:.....:       :.|..|..|::::|  |..
  Fly   422 GWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRE 486

Human   557 LDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPK--APQWPPYTAGAQQYVSLDLRPLE-V 618
            |..|...|.::....:.::..|.:||:||:|| |.:..  .|.|.|    |..|      |:| .
  Fly   487 LFVSAVPTQKDLELRELMLHLWVSFAKTGNPN-PTNVSFHLPNWSP----ASSY------PVEFA 540

Human   619 RRGLRAQACA---------------FWNRFLPKL 637
            |.|.:.:..|               ||....|.|
  Fly   541 RLGTKMEDSASIFRLENELMQHRVDFWRDLQPHL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	198/590 (34%)
		AChE_tetra	645..678	CDD:430146
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	198/590 (34%)