DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and Pdia6

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_082235.2	Gene:	Pdia6 / 71853	MGIID:	1919103	Length:	440	Species:	Mus musculus

Alignment Length:	294	Identity:	58/294 - (19%)
Similarity:	93/294 - (31%)	Gaps:	104/294 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLTGSSNVVVL----FNK------------------NNCQRCV-EYENMVTKIRAQLEETLSAIV 74
            |.:.|.:|:.|    ||:                  .:|||.. |::...|.::       ..:.
Mouse    20 LYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALK-------DVVK 77

  Fly    75 VQSVDS----NLVSIYDPSKEPALVFF--RRGIPILYHGEINDDEILDFFNDNLEPAVK------ 127
            |.:|::    :|...|.....|.:..|  .:..|..|.|....:.|:|.....|...||
Mouse    78 VGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGR 142

  Fly   128 ---------------------ELSDDNFEHLTQASSGATTGDWFIFFSSAECTVCQRLYAVW--- 168
                                 ||:||.|:.....|...    |.:.|.:..|..|:.|...|
Mouse   143 SGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDV----WMVEFYAPWCGHCKNLEPEWAAA 203

  Fly   169 -----ESVGGKLKRKLNIARMNSLESGISTATRLGVLEAPAFIFLRQGKMYKYSAKQYSPEAFVQ 228
                 |...||:|.....|.||.:     .|:|.|:...|.....::|:         ||..:
Mouse   204 ATEVKEQTKGKVKLAAVDATMNQV-----LASRYGIKGFPTIKIFQKGE---------SPVDY-- 252

  Fly   229 FAEKGYTQ-----------SHPQPVPAIPSAVNE 251
              :.|.|:           |...|.|.:...:||
Mouse   253 --DGGRTRSDIVSRALDLFSDNAPPPELLEIINE 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	27/137 (20%)
Pdia6	NP_082235.2	PDI_a_P5	26..128	CDD:239299	20/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..161		0/21 (0%)
		PDI_a_P5	161..266	CDD:239299	28/126 (22%)
		P5_C	275..404	CDD:239281	3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..440
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	437..440
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910