DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and TXNDC16

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_065835.2	Gene:	TXNDC16 / 57544	HGNCID:	19965	Length:	825	Species:	Homo sapiens

Alignment Length:	292	Identity:	61/292 - (20%)
Similarity:	105/292 - (35%)	Gaps:	74/292 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LTGSSNVVVLFNKNNCQRCVEYENMVTKIRAQLEETLSAIVVQSVD------SNLVSIYDPSKE- 91
            |.|.:.|::|...:......:..|:|.| ||:....:..:|:..||      .|.:.|.:..::
Human   297 LLGKAGVLLLLRDSLEVNIPQDANVVFK-RAEEGVPVEFLVLHDVDLIISHVENNMHIEEIQEDE 360

  Fly    92 ------PALVFFRRGIPILYHGEINDDEILD-FFNDN-----LEPAVKELSDDNFEHLTQASSGA 144
                  |.:             ::.|||:.: .|.|.     ||..| ||:::.|.....||
Human   361 DNDMEGPDI-------------DVQDDEVAETVFRDRKRKLPLELTV-ELTEETFNATVMAS--- 408

  Fly   145 TTGDWFIFFSSAECTVCQRLYAVWES-----------VGGKLK--RKLNIARMNSLESGISTATR 196
               |..:.|           ||.|::           |..|||  ..:.:.|:|..:.. ...|:
Human   409 ---DSIVLF-----------YAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWS-DVCTK 458

  Fly   197 LGVLEAPAFIFLRQGKMYKYSAKQYSPEAFVQFAEKGYTQSHPQPVPAIPSAVNEFLGPLQSYFA 261
            ..|.|.|.....::|:.....|.....|..::|.:.... |:|..:.:|..|        :.|.:
Human   459 QNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRI-SYPVNITSIQEA--------EEYLS 514

  Fly   262 AENITSLATLSIFALVALLFVGKKVAKIFSSE 293
            .|....|...|..:::.|.....|.||...||
Human   515 GELYKDLILYSSVSVLGLFSPTMKTAKEDFSE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	23/115 (20%)
TXNDC16	NP_065835.2	PDI_a_family	394..492	CDD:239259	24/116 (21%)
		Thioredoxin_6	533..722	CDD:290560	5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..787
		Mediates endoplasmic reticulum retention. /evidence=ECO:0000269\|PubMed:25122923	816..819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900