DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and pdia5

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001107048.1	Gene:	pdia5 / 556162	ZFINID:	ZDB-GENE-030521-5	Length:	528	Species:	Danio rerio

Alignment Length:	364	Identity:	76/364 - (20%)
Similarity:	133/364 - (36%)	Gaps:	111/364 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHIVSVVIIALSL-GCAVGQDLRRVDD-TELIQLLTGSSNVVVLFNKNNCQRCVEYENMVTKIR 63
            |...:|:|.:..:| ...|...:.:|:| .:..:||...:||:||:.|:           .:...
Zfish    16 MFIFLSLVAVTSALQAVKVSPLIEKVNDHKDFKKLLRTRTNVLVLYTKS-----------ASSGD 69

  Fly    64 AQLEETLSAIVVQSV------------DS------NLVSIYDPSKEPALVFFRRGIPIL------ 104
            |.|:  |.:.|.|:|            ||      ..|.: |||.:      .:|:.:|
Zfish    70 AHLK--LLSDVAQAVKGQGTIAWVNCGDSEGRKLCKKVKV-DPSSK------TKGVELLHYKDGT 125

  Fly   105 YHGEIND----DEILDFFND-------NLEPAVKEL----SDDNFEHLTQASSGATTGDWFIFFS 154
            :|.|.|.    ..::.|..|       ...|..|::    |:.:|..|.:......    .:.|.
Zfish   126 FHTEYNRPATFKSMVAFLKDPAGAPLWEENPEAKDVVHIESEKDFRKLLKREERPI----LMMFY 186

  Fly   155 SAECTVCQRLYAVWESVGGKLKRKLNIARMNSLESGISTATRLGVLEA------PAFIFLRQGKM 213
            :..|.||:|:..:::....:.|.|..:|.||     :..|...||.:.      |.|.:..:||
Zfish   187 APWCGVCKRMQPIFQQAATETKGKYVLAGMN-----VHPAEFDGVKQEFSVKGYPTFCYFEKGK- 245

  Fly   214 YKYSAKQYSPEAFVQFAEKGYTQ--SHPQP----VPAIP-----SAVNEFLGPLQSYFAAENITS 267
            :.:..:.|..      ..|..|.  .:|||    .|.:|     |||..........|..|:.::
Zfish   246 FLHHYENYGA------TSKDITDWLKNPQPPQPKTPEVPWSESGSAVFHLTDDSFDSFLEEHPSA 304

  Fly   268 LATLSIFALVALLFVG------KKVAKIFSSEPAKTKNK 300
            |          ::|..      ||:...: .:.|:|.||
Zfish   305 L----------IMFYAPWCGHCKKMKPEY-DDAAETLNK 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	22/112 (20%)
pdia5	NP_001107048.1	PDI_b_PDIR_N	36..147	CDD:239365	28/130 (22%)
		PDI_a_PDIR	160..264	CDD:239295	23/119 (19%)
		ER_PDI_fam	181..512	CDD:273457	38/179 (21%)
		PDI_a_PDIR	285..388	CDD:239295	12/59 (20%)
		PDI_a_PDIR	407..510	CDD:239295
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810