DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and DNAJC10

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_061854.1	Gene:	DNAJC10 / 54431	HGNCID:	24637	Length:	793	Species:	Homo sapiens

Alignment Length:	245	Identity:	59/245 - (24%)
Similarity:	96/245 - (39%)	Gaps:	35/245 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SVDSNLVSIYDPSKEPALVFFRRGIPILYHGEINDDEILDFFNDNLEPAVKELSDDNFEHL-TQA 140
            :|...|.::|:....|..|.|.:.....|.|..:.::||:|..|.:.|:|..|:...|..| ||.
Human   509 TVHEGLCNMYNIQAYPTTVVFNQSNIHEYEGHHSAEQILEFIEDLMNPSVVSLTPTTFNELVTQR 573

  Fly   141 SSGATTGDWFIFFSSAECTVCQRLYAVWESVGGKLKRKLNIARMNSLESGISTATRLGVLEAPAF 205
            .....   |.:.|.|..|..||.|...|:.:...|...:|:..:: .:...|...:..|...|..
Human   574 KHNEV---WMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSID-CQQYHSFCAQENVQRYPEI 634

  Fly   206 IFL--RQGKMYKY-SAKQYSPEAF------VQFAEKGYTQSHPQPV-PAIPSAVNEFL------- 253
            .|.  :..|.|.| |...::.:|:      :.|..:..|...||.. ..:....|.::
Human   635 RFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFYAPW 699

  Fly   254 -GPLQSYFAAENITSLATLSIFALVALLFVGK-KVAKIFSSEPAKTKNKS 301
             ||.|: ||.|          |.|:|.:..|| |..|:.....|:|..|:
Human   700 CGPCQN-FAPE----------FELLARMIKGKVKAGKVDCQAYAQTCQKA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	24/112 (21%)
DNAJC10	NP_061854.1	DnaJ	34..>132	CDD:223560
		PDI_a_ERdj5_N	129..229	CDD:239301
		Trxb 1	235..350
		Trxb 2	348..463
		PDI_a_ERdj5_C	453..550	CDD:239302	10/40 (25%)
		PDI_a_ERdj5_C	556..663	CDD:239302	26/110 (24%)
		PDI_a_ERdj5_C	670..775	CDD:239302	20/80 (25%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	790..793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810