DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and PDILT

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_777584.1	Gene:	PDILT / 204474	HGNCID:	27338	Length:	584	Species:	Homo sapiens

Alignment Length:	142	Identity:	33/142 - (23%)
Similarity:	58/142 - (40%)	Gaps:	37/142 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QDLRRVDDTELIQLLTGSSNVVVLFNKNN----------CQRCV-----------EYENMVTKIR 63
            :::.:..|..|::.|.|.:..||:|:|..          .::|.           :|:|..|.|.
Human   378 EEIPKYWDQGLVKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIII 442

  Fly    64 AQLEETLSAIVVQSVDSNLVSIYDPSKEPALVFFRRGI--PILYHGEINDDEILDFFNDNLEPAV 126
            |:::.|.:.|.:..:|          :.|....|..|.  .:||.||    ..|..|:|.||..:
Human   443 AKIDVTANDIQLMYLD----------RYPFFRLFPSGSQQAVLYKGE----HTLKGFSDFLESHI 493

  Fly   127 KELSDDNFEHLT 138
            |...:|..|.|:
Human   494 KTKIEDEDELLS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	4/12 (33%)
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	31/136 (23%)
PDILT	NP_777584.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	581..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900