DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and PDIA5

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_006801.1	Gene:	PDIA5 / 10954	HGNCID:	24811	Length:	519	Species:	Homo sapiens

Alignment Length:	290	Identity:	57/290 - (19%)
Similarity:	109/290 - (37%)	Gaps:	68/290 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHIVSVVIIALSLGCAVGQDLRRVDD-TELIQLLTGSSNVVVLFNKNNCQRCVEYENMVTKIRA 64
            :|..:.||:.:......|...:.|:.| .:|.:||...:||:||::|             :::.|
Human     9 LLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSK-------------SEVAA 60

  Fly    65 QLEETLSAIVVQSVDSN--------------------LVSIYDPSKEPALVFFRRGIPILYHGEI 109
            :....|.:.|.|:|...                    .|.:....|:..|..::.|   .:|.|.
Human    61 ENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDG---AFHTEY 122

  Fly   110 ND----DEILDFFND-------NLEPAVKEL----SDDNFEHLTQASSGATTGDWFIFFSSAECT 159
            |.    ..|:.|..|       ..:|..|::    |:.:|..|.:......    .|.|.:..|:
Human   123 NRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPL----LIMFYAPWCS 183

  Fly   160 VCQRLYAVWESVGGKLKRKLNIARMNSLESGI-STATRLGVLEAPAFIFLRQGK-MYKYSAKQYS 222
            :|:|:...::....:|:....:|.||...|.. :......|...|...:..:|: :::|.....:
Human   184 MCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGST 248

  Fly   223 PEAFVQFAEKGYTQSHPQP----VPAIPSA 248
            .|..|::.:      :|||    ||..|.|
Human   249 AEDIVEWLK------NPQPPQPQVPETPWA 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	20/108 (19%)
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365	25/126 (20%)
		PDI_a_PDIR	152..256	CDD:239295	19/107 (18%)
		PTZ00102	168..512	CDD:240266	23/115 (20%)
		PDI_a_PDIR	277..379	CDD:239295
		PDI_a_PDIR	398..501	CDD:239295
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	516..519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900