DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11790 and Txndc5

DIOPT Version :9

Sequence 1:	NP_651326.1	Gene:	CG11790 / 42999	FlyBaseID:	FBgn0039265	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_663342.3	Gene:	Txndc5 / 105245	MGIID:	2145316	Length:	417	Species:	Mus musculus

Alignment Length:	305	Identity:	70/305 - (22%)
Similarity:	118/305 - (38%)	Gaps:	67/305 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SVVIIALSLGCAVGQDLRRVD-------DTELIQLLT---------GSSNVVVLFNK--NNCQRC 52
            ::..:.|.||...|...:.|:       |.....|.|         .:::.|:.|..  .:|||.
Mouse    17 ALATLLLLLGARKGARAQEVEADSGVEQDPHAKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRL 81

  Fly    53 VEYENMVTKIRAQLEETLSAIVVQSV----DSNLVSIYDPSKEPALVFFRRG-IPILYHG----E 108
            ....|.:......:|:  :.:.|..|    ||::.|.......|.|.||:.| ..:.|.|    |
Mouse    82 QPTWNDLGDKYNSMED--AKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVKYQGPRDFE 144

  Fly   109 INDDEILDFFNDNLEPA-----------------VKELSDDNFE-HLTQASSGATTGDWFIFFSS 155
            ..::.:|...|:  |||                 :.|||.:||| |::|       |:.||.|.:
Mouse   145 TLENWMLQTLNE--EPATPEPEAEPPRAPELKQGLYELSANNFELHVSQ-------GNHFIKFFA 200

  Fly   156 AECTVCQRLYAVWE--SVGGKLKRKLNIARMNSLESGISTATRLGVLEAPAFIFLRQGKMYKYSA 218
            ..|..|:.|...||  ::|.:....:.|.:::..:. .:..:...|...|..::.|.||    ..
Mouse   201 PWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH-YAVCSEHQVRGYPTLLWFRDGK----KV 260

  Fly   219 KQYSPEAFVQFAEKGYTQSHPQPVPAIPSAVNEFLGPLQSYFAAE 263
            .||..:..:: :.:.|.||..|...|.|..|.....|:   .|||
Mouse   261 DQYKGKRDLE-SLRDYVQSQLQGSEAAPETVEPSEAPV---MAAE 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11790	NP_651326.1	PDI_a_family	127..230	CDD:239259	26/105 (25%)
Txndc5	NP_663342.3	PDI_a_ERp46	47..150	CDD:239303	22/104 (21%)
		ER_PDI_fam	52..417	CDD:273457	63/270 (23%)
		PDI_a_ERp46	176..276	CDD:239303	26/112 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..302		8/24 (33%)
		PDI_a_ERp46	308..409	CDD:239303
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810