DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ythdf and ECT10

DIOPT Version :9

Sequence 1:	NP_001262943.1	Gene:	Ythdf / 42995	FlyBaseID:	FBgn0039261	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_974954.1	Gene:	ECT10 / 835931	AraportID:	AT5G58190	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	229/537 - (42%)	Gaps:	142/537 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 PAAQSFRNEND------QPSTKLDNR-----TSDEAQN-------QEVVAAPKKTTWASIASQPA 156
            ||:.|..|:.:      :.....||.     :.|:.:|       ..||.:|....:.::...|.
plant     3 PASSSSSNQRNRIVSSGERPVMADNGVQQQVSHDDGRNIVSSSYSSSVVPSPDPAPYYNVLQTPT 67

  Fly   157 KL---------------------TSRAASTT------------SNS----KKKGPGMPPPPMVPG 184
            .|                     ..|.|:||            .||    :..|.|..|.|.|..
plant    68 NLYHYDWDIANSGYAQGINTWDGYPRYATTTPEAMHVPPVVYNDNSSLMYQYPGYGFNPYPSVML 132

  Fly   185 KHNLDVNVWDLPNNKPPPVPSP------PSPIDL---------------GYSDLSSDFSISSNTA 228
            :..:.|:    |...|.|..:|      ||.||.               .||....|.|::|:..
plant   133 EGQIPVS----PAYYPQPFGAPSAMHYLPSDIDPTSAAYMIPYGQYGGGNYSGNQGDISLTSHIP 193

  Fly   229 PPLGARAEKVHKDTENFL-KYEHKGLGNNNNFSRAKVSPTGPV-RRNLGPQQPVHHAA--PRPAT 289
            .|          .|...| .|:|       |.|:..:..:|.. ..:||   ..:|..  ..|::
plant   194 YP----------QTMGILGPYDH-------NASQVALHGSGVASSSSLG---GYYHVGSYQNPSS 238

  Fly   290 NAGPFGPPNARR--HDGGPHPSRNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEEL 352
            ....:|..|..|  .|.|....::.....:.|...|:....||. ..:.:|.|:|...
plant   239 TPSYYGVDNRVRLTPDIGKRREKDQGSISSTSDLYGNRGPRASS-RVKSKNSSKPCST------- 295

  Fly   353 PVDSQLVLDELKDKNNYNPK---------VLDLKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTD 408
                  :.|...|.:...|.         |.|.|   :|:||::||:|||::||||||.:|.||.
plant   296 ------IGDSASDSSTAGPNPSLYNHPEFVTDYK---NAKFFIVKSFSEDNVHRSIKYNVWASTP 351

  Fly   409 HGNKRLDDAFKERHEEGGN--IMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVK 471
            ||||:||.|:::..:.||.  |.||||||.||.|||:::|:.|||:...:..|.||:|.|:|.||
plant   352 HGNKKLDTAYRDAEKMGGKCPIFLFFSVNASGQFCGVSEMVGPVDFEKDAGYWQQDRWSGQFPVK 416

  Fly   472 WIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKK 536
            |..|||:||....||.|:||:||.||:|||:|||...:|||:|:|...|...|||.|||.:|::.
plant   417 WHIVKDIPNNRFCHILLQNNDNKPVTHSRDSQEVKLRQGIEMLRIFKEYEAHTSILDDFGYYDEL 481

  Fly   537 QEEEVSSKRPPMHGPDG 553
            :.::|        |.||
plant   482 EGQKV--------GEDG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	76/137 (55%)
ECT10	NP_974954.1	YTH	325..463	CDD:282058	76/137 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1083
eggNOG	1	0.900	-	-		E1_KOG1901
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000639
OrthoInspector	1	1.000	-	-		otm2739
orthoMCL	1	0.900	-	-		OOG6_102335
Panther	1	1.100	-	-	O	PTHR12357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X383
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770