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Protein Alignment Ythdf and YTHDF1

DIOPT Version :9

Sequence 1:	NP_001262943.1	Gene:	Ythdf / 42995	FlyBaseID:	FBgn0039261	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_060268.2	Gene:	YTHDF1 / 54915	HGNCID:	15867	Length:	559	Species:	Homo sapiens

Alignment Length:	640	Identity:	212/640 - (33%)
Similarity:	283/640 - (44%)	Gaps:	198/640 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGVDQMKIPGNTAKSVEERNIPWSQQVDEASYE----NLSSPTHDEVSGNDNSMQFQYPP---FN 59
            :.||..:..|...| |:..::.....|.:..:|    ..|:.::...|.:|..:...|||   |.
Human     4 TSVDTQRTKGQDNK-VQNGSLHQKDTVHDNDFEPYLTGQSNQSNSYPSMSDPYLSSYYPPSIGFP 67

  Fly    60 FKENCNTPWNNMNK---------GRKANAN----HDSYRRHGHSIPNNTRRDEHQVN-------- 103
            :..| ..||:....         |:.:|.:    ||:.......:.||..  :|:.|
Human    68 YSLN-EAPWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIY--QHRFNFFPENPAF 129

  Fly   104 -PWNSRKPAAQSFRNE------------------NDQPSTKLDNRTSDEAQNQ------------ 137
             .|.:.....|..::.                  :.||....|..:.....|.
Human   130 SAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQPGFHSDTLSKAPGMNSLEQGMVGLKIGD 194

  Fly   138 ----------EVVAA-------------------PKKTTWASIASQPAKLTSRAASTTSNSKKKG 173
                      .||::                   .|.|:||:|||:|||  .:....|.:....|
Human   195 VSSSAVKTVGSVVSSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAK--PQPKMKTKSGPVMG 257

  Fly   174 PGMPPPPMVPGKHNLDVNVWDLPNNKPP----PV----PSP---PSPIDLGYSDLSSDFSISSNT 227
            .|:||||:   |||:|:..||   ||.|    ||    |||   |.|               ...
Human   258 GGLPPPPI---KHNMDIGTWD---NKGPVPKAPVPQQAPSPQAAPQP---------------QQV 301

  Fly   228 APPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPRPATNAG 292
            |.||.|:...:.:.     :|:                         .||||.......|.....
Human   302 AQPLPAQPPALAQP-----QYQ-------------------------SPQQPPQTRWVAPRNRNA 336

  Fly   293 PFGPPNARRHDGGPHPSRNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEELPVDSQ 357
            .||                  :||...|               |.|....|:..||..   |:|.
Human   337 AFG------------------QSGGAGS---------------DSNSPGNVQPNSAPS---VESH 365

  Fly   358 LVLDELKDKNNYNPKVLD--LKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKE 420
            .||::||..::||||..:  ||   |.|.|:|||||||||||||||.|||||:|||||||.||:.
Human   366 PVLEKLKAAHSYNPKEFEWNLK---SGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRC 427

  Fly   421 RHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVPNGTLRH 485
            ...: |.:.|.|||||||||||:|:|.:||||.:::.|||||||:|||.|:||:||||||..|||
Human   428 MSSK-GPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLRH 491

  Fly   486 IRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEE 540
            ||||||:||.|||||||||||.:|..:||:|:.||.|:|||||||.||||:||||
Human   492 IRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEE 546

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.