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Protein Alignment Ythdf and YTHDF2

DIOPT Version :9

Sequence 1:	NP_001262943.1	Gene:	Ythdf / 42995	FlyBaseID:	FBgn0039261	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001166599.1	Gene:	YTHDF2 / 51441	HGNCID:	31675	Length:	579	Species:	Homo sapiens

Alignment Length:	417	Identity:	179/417 - (42%)
Similarity:	233/417 - (55%)	Gaps:	86/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 VAAPKKTTWASIASQPAKLTSRAASTTSNSKKKGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVP 204
            :|.||..:||.|||:|||...:..:....:   |..:||||:   |||:|:..||   ||.|...
Human   231 IAPPKPASWADIASKPAKQQPKLKTKNGIA---GSSLPPPPI---KHNMDIGTWD---NKGPVAK 286

  Fly   205 SPPSPI--DLGYSDLSSDFSI--SSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVS 265
            :|...:  ::|.....|...:  .:|.:||: |:| .|.:.|:                   .:.
Human   287 APSQALVQNIGQPTQGSPQPVGQQANNSPPV-AQA-SVGQQTQ-------------------PLP 330

  Fly   266 PTGPVRRNLGPQ----QPVHHAAPRPATNAGP-FGPPNARRHDGGPHPSRNSERSGNYSSFRGSE 325
            |..|....|..|    ||....|||   |.|. ||      |:|.........::|:.|:
Human   331 PPPPQPAQLSVQQQAAQPTRWVAPR---NRGSGFG------HNGVDGNGVGQSQAGSGST----- 381

  Fly   326 FESASKFEYRDENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIK 388
                                       |.:...||::|:..||||||..|  ||   ..|.|:||
Human   382 ---------------------------PSEPHPVLEKLRSINNYNPKDFDWNLK---HGRVFIIK 416

  Fly   389 SYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYN 453
            |||||||||||||.|||||:|||||||.|::..:.: |.:.|.|||||||||||:|:|.:.||||
Human   417 SYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGK-GPVYLLFSVNGSGHFCGVAEMKSAVDYN 480

  Fly   454 STSSVWSQDKWRGKFKVKWIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILH 518
            :.:.|||||||:|:|.|:||:||||||..||||||||||||.|||||||||||.:|..:||:|:.
Human   481 TCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIA 545

  Fly   519 SYNHSTSIFDDFFHYEKKQEEEVSSKR 545
            ||.|:|||||||.||||:||||.|.|:
Human   546 SYKHTTSIFDDFSHYEKRQEEEESVKK 572

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.