Protein Alignment Ythdf and ythdc1

DIOPT Version :10

• Sequence 1: NP_651322.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001007411.1
• Gene: ythdc1 / 492769
• ZFINID: ZDB-GENE-041114-114
• Length: 679
• Species: Danio rerio
• Alignment Length: 703
• Identity: 150/703 - (21%)
• Similarity: 256/703 - (36%)
• Gaps: 158/703 - (22%)

  Fly    97 RDEHQVNPWNSRKPAAQSFRNENDQPSTKLDNRTSD--EAQNQEVVAAPKKTTWASIASQPAKLT 159
            :|:...||           .:|:|....|...|..|  :||:.:.:.|....|     .||.|
Zfish    26 QDDELYNP-----------ESEHDVNEKKGSKRKHDRGDAQDAKRLRASGHNT-----RQPMK-- 72

  Fly   160 SRAA-STTSNSKK-KGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVPSPPSPIDLGYSD--LSSD 220
             ||| |:.||.|| ..|        .|:|..: :::|...|......:..:.:..||.:  |||.
Zfish    73 -RAAPSSGSNGKKTSNP--------RGRHAPE-DLYDDRKNHSGRGGASRADLSKGYGEKGLSSS 127

  Fly   221 FSISSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVS-----PTG-PVRRNLGPQQP 279
            ........|.:....||:.:.:|       :..|..:..||.:.:     .|| .|..:.|....
Zfish   128 RDSQRRIKPLMPELTEKMRRTSE-------ESAGRASRSSREEEAHSEEYATGSSVASSEGNCSD 185

  Fly   280 VHHAAPRPATNAGPFGPPNARRHDGGPHPSRNSE---------RSGN-------YSSFRGSEFES 328
            |......|.......|.......:.|.......|         |.||       .|....|..||
Zfish   186 VEEEGAMPEEGEEKEGEEEEEEEEEGDDDDDEEEEYVLEEEDAREGNEQNDYDTRSEASDSRSES 250

  Fly   329 ASKFEYRDENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLDLKKAGSARFFVIKSYSED 393
            .|..:....:.:...:|:.:.::....|..|.|..||:.|....:|     ..||||:|||.:.:
Zfish   251 VSFSDGESVHSASGSDASGSEKKHEKLSSSVRDVRKDRINKLKHIL-----REARFFLIKSNNHE 310

  Fly   394 DIHRSIKYEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSV 458
            ::..:....:|.:.....|:|:.||:...    :::|.|||..||.|.|.|::.:...:..:...
Zfish   311 NVSLAKAKGVWSTLPVNEKKLNAAFRAAR----SVVLIFSVRESGKFQGFARLSSESHHGGSPIH 371

  Fly   459 W------SQDKWRGKFKVKWIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEV------------ 505
            |      :.....|.||:.||..:::|.....|:....||:|.|...||.||:
Zfish   372 WVLPAGMNAKMLGGVFKIDWICRRELPFTKTAHLANPWNEHKPVKIGRDGQEIEPECGTELCMLF 436

  Fly   506 PNDKGIEVLQILHSYNHSTSIFDD------FFHYE-------KKQEEEV---SSKRP-------- 546
            |:|:.|::.|::|...|...:..:      ..|.|       :::.||.   :.|||
Zfish   437 PHDESIDLYQVIHKMRHKRRMHSEPRSRGRLPHREPVPRDMGRRRPEEYDMHNRKRPRIDYTPEF 501

  Fly   547 ---PMHGPDGNNHAPAPLARSFNRQADDKDRDRDGRGGMSQKHFNSG------GGAGF------- 595
               |....|..|   .|:.|.|:....|...:......|.:.|.|.|      |.|.:
Zfish   502 PQRPGFMQDPRN---PPVDRRFSGVRRDVFLNGSYNDYMREFHHNIGPPPPWQGMAPYPGMEHPP 563

  Fly   596 RNPGHRGGAGSGGSHNNYSEYRRGFDIHKSSSDYQFKDR--------DGPDFD-RENDF------ 645
            ::|.::.......:|..||.:      |....|.:|:::        ...|:| |.:||
Zfish   564 QHPYYQHHPPPPQAHPPYSGH------HPMPHDARFREKRVVRSFASSLHDYDMRVDDFLRRTQA 622

  Fly   646 ---GSHYGSNNRKNEYKHNNTNKARLKTRDRDFSTEQIKIGVRFKDTDKDKMR 695
               |.......|..:.:.:.....| :.|:|:...|:.:...|.:|.:::|.|
Zfish   623 VVSGRRSRPRERDRQRERDRPRDGR-RDRERERGRERDRERERIRDREREKER 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_651322.1	YTH	382..518	CDD:461195	41/153 (27%)
ythdc1	NP_001007411.1	YTH	300..436	CDD:410979	36/139 (26%)