Protein Alignment Ythdf and ythdf2

DIOPT Version :10

• Sequence 1: NP_651322.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_005158820.1
• Gene: ythdf2 / 393220
• ZFINID: ZDB-GENE-040426-948
• Length: 613
• Species: Danio rerio
• Alignment Length: 620
• Identity: 230/620 - (37%)
• Similarity: 297/620 - (47%)
• Gaps: 147/620 - (23%)

  Fly    24 WSQQVDE-----ASYENLSSPTH----DEVSG-----NDNSMQFQYPPFN-FKENCNTP-W-NNM 71
            ||...|.     |||..||:..|    |.:.|     .:|....|: .|| |....:.| | |:.
Zfish    75 WSTGGDPPMPYLASYGQLSNGEHHFLPDAMFGQSGALGNNPFLGQH-GFNFFPSGIDFPAWGNSS 138

  Fly    72 NKGRKA-NANHDSYRRHGHSIPNNTRRDEHQVNPWNSRKPAAQSF-RNENDQPSTKLDNRTSDEA 134
            ::|:.. ::.:.|...:..|.......|..  :|:.:.:|..::. .|..||....|.....|.|
Zfish   139 SQGQSTQSSGYSSSYAYAPSTLGGAMIDGQ--SPFAANEPLNKAVGMNSLDQGMAGLKIGAGDMA 201

  Fly   135 QN-----------QEVVAAP----------KKTTWASIASQPAKLTSRAASTTSNSKKK----GP 174
            ..           .:|..||          |..:||.|||:|||...:.       |.|    |.
Zfish   202 PKVVGSGLPGGPLSQVSTAPTMPPASMAPAKTASWADIASKPAKPQPKL-------KTKGGLGGT 259

  Fly   175 GMPPPPMVPGKHNLDVNVWDLPNNKPPPVPSPPSPIDLGYSDLSSDFSISSNTAPP------LGA 233
            .:||||:   |||:|:..||...|    :|.|.:|         ...|:.:|..||      .||
Zfish   260 NLPPPPI---KHNMDIGTWDNKGN----MPKPAAP---------QQTSLPTNGQPPNQSSPQPGA 308

  Fly   234 RAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPRPATNAGPFGPPN 298
            .|..|          ....|.|..     .|.|||         |.|.|..|       |.|.|.
Zfish   309 TAGGV----------PQLPLSNGQ-----LVPPTG---------QLVQHPLP-------PGGQPG 342

  Fly   299 A--RRHDGGPHPSRNSE---------RSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEEL 352
            |  .:...||..|:.|:         |:..:....|...:|             |..:......:
Zfish   343 AVPPQLSQGPPASQPSQPTRWVPPRNRANGFGDAAGGPGQS-------------PPNSGMGGITV 394

  Fly   353 PVDSQLVLDELKDKNNYNPKVLDLK-KAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRLDD 416
            |.:...||::|:..||||||..|.. |.|  |.|:|||||||||||||||.|||||:|||||||.
Zfish   395 PAEPHPVLEKLRMVNNYNPKDFDWNPKHG--RVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDA 457

  Fly   417 AFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVPNG 481
            |::....: |.:.|.|||||||||||:|:|.:|||||:.:.|||||||:|:|.|:||:||||||.
Zfish   458 AYRSLANK-GPLYLLFSVNGSGHFCGVAEMRSPVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNS 521

  Fly   482 TLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEEVSSKRP 546
            .||||||||||||.|||||||||||.||..:||:|:.||.|:|||||||.||||:||||.|.|:.
Zfish   522 QLRHIRLENNENKPVTNSRDTQEVPLDKARQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKKV 586

  Fly   547 PMHGPD--GNNHAPAPLARSFNRQADDKDRDRDGR 579
            .:.|.|  .||.     :||..|.     :||.||
Zfish   587 EVQGSDPYSNNS-----SRSHYRM-----QDRQGR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_651322.1	YTH	382..518	CDD:461195	96/135 (71%)
ythdf2	XP_005158820.1	Med15	<173..>411	CDD:312941	71/304 (23%)
		YTH	424..557	CDD:461195	95/133 (71%)