Protein Alignment Ythdf and Ythdc1

DIOPT Version :9

• Sequence 1: NP_001262943.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_647811.2
• Gene: Ythdc1 / 38420
• FlyBaseID: FBgn0027616
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 632
• Identity: 128/632 - (20%)
• Similarity: 209/632 - (33%)
• Gaps: 172/632 - (27%)

  Fly    15 KSVEERNIPWSQQVDEASYENLSSPTHDEVSGNDNSMQFQYPPFNFKENCNTPWNNMNKGRKANA 79
            ::..::.:|..:..|       ....|..:..|:..:..:...|.|........:|......:..
  Fly     3 RAARKQTLPMREMAD-------LDAVHLGLDENEADIAEELQDFEFNTRSEASESNGGDSSDSEP 60

  Fly    80 NHDSYRRHGHSIPNNTRRDEHQVNPWNSRKPAAQSFRNENDQPSTK--LDNRTSDEAQNQEVVAA 142
            :..|......|:..:::|        .::|||.||.:...:..|:|  ..|:...|...:|:...
  Fly    61 SISSVSTATSSLAGSSKR--------KTKKPAKQSPQPAVETKSSKSSAKNKAKREPTPEELNGG 117

  Fly   143 PKKTTWASIASQPAKLTSRAASTTSNSKKKGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVPSPP 207
            .||   ....|...|.||..||....||........|.....:..:..|..|...:|
  Fly   118 KKK---KRTDSGTKKTTSSEASDKVKSKSPDTEDRQPSAKKSRTKIPSNANDSAGHK-------- 171

  Fly   208 SPIDLGYSDLSSDFSISSNTAPPLGA-RAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVR 271
                       ||.|.:.:..|.|.. .::....|:::..:::..| ||.....|.|
  Fly   172 -----------SDLSEAEDEKPSLPTLESDSESSDSDSGTQHKRNG-GNGGGNGRGK-------- 216

  Fly   272 RNLGPQQPVHHAAPRPATNAGPFGPPNARRHDGGPHPSRNSERSGNYS-SFRGSEFESASKFEYR 335
                           |::.:..              |.::|...|.:| |.:|.::.:...:.:|
  Fly   217 ---------------PSSKSST--------------PEKDSVGGGTHSHSQKGYDYMTKLNYLFR 252

  Fly   336 DENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLDLKKAGSARFFVIKSYSEDDIHRSIK 400
            |                                             .|||:|||.:.|::..|..
  Fly   253 D---------------------------------------------TRFFLIKSNNSDNVQLSKN 272

  Fly   401 YEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVW------ 459
            ..:|.:....:..|:.||||..    |::|.||||.||.|.|.|:|..|...:.....|
  Fly   273 KSVWATLPQNDANLNQAFKEAR----NVLLIFSVNESGKFAGFARMAAPSRRDIPQVAWVLPPSI 333

  Fly   460 SQDKWRGKFKVKWIYVKDVP-NGTLRHIRLENNENKSVTNSRDTQEV------------PNDKGI 511
            |.....|..::.||..|::. |.|| |:....||.|.|...||.||:            |.|:.|
  Fly   334 SPKALGGVIELDWICRKELSFNATL-HLHNTWNEGKPVKIGRDGQEIEPKIGGELCRLFPEDEQI 397

  Fly   512 EVLQILHSYNHSTSIF-DDFFHYEKKQEEEVSSKRPPMHGPDGNNHAPAPLARSFNRQADDKDRD 575
            |:..||.....:..:. :...|...|....:||:.   ||..|              :...:..:
  Fly   398 ELTPILKKSKETARVMREKGIHVIYKPPRSLSSRG---HGGGG--------------RGGGRGSN 445

  Fly   576 RDGRGGMSQKHFNSGGGAGFRNP-GHRGGAG---SGGSHNNYSEYRR 618
            .|..|.|  :|..|..||....| .|..|.|   .||...:.|.||:
  Fly   446 HDHLGPM--RHKRSYHGAPHHRPYRHHHGMGLPPGGGFKRSGSPYRQ 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	50/154 (32%)
Ythdc1	NP_647811.2	YTH	254..392	CDD:309322	45/142 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456487
Domainoid	1	1.000	44	1.000	Domainoid score	I3593
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970