Protein Alignment Ythdf and Ythdf3

DIOPT Version :9

• Sequence 1: NP_001262943.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_006232230.1
• Gene: Ythdf3 / 361920
• RGDID: 1305234
• Length: 588
• Species: Rattus norvegicus
• Alignment Length: 657
• Identity: 221/657 - (33%)
• Similarity: 291/657 - (44%)
• Gaps: 213/657 - (32%)

  Fly    11 GNTAKSVEERNIPWSQQVDEASYE-NLSSPTHDEVSGNDNSMQFQYPPFN-------FKENCNTP 67
            |..:.||:..:|.....|::..:| .|||.|      |.|:   .|||.:       :..:...|
  Rat    16 GEESFSVQNGSIHQKDAVNDDDFEPYLSSQT------NQNN---SYPPMSDPYMPSYYAPSIGFP 71

  Fly    68 -------WNNMNK---------GRKANANHDSYRRHGHSIPN----------NTR--RDEHQVN- 103
                   |:....         |:.:|..|       |.||:          ||.  ..:|..|
  Rat    72 YSLGEAAWSTAGDQPMPYLTTYGQMSNGEH-------HYIPDGVFSQPGALGNTPPFLGQHGFNF 129

  Fly   104 --------PWNSRKPAAQSFRNE-------------------------NDQPS------------ 123
                    .|.:.....||.:|.                         ||..|
  Rat   130 FPGNADFSTWGTSGSQGQSTQNSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSKVPGISSIEQGM 194

  Fly   124 -------------TKL-------DNRTSDEAQNQEVV--AAPKKTTWASIASQPAKLTSRAASTT 166
                         ||.       ...||....|...|  ||||.|:||:||.:|||...:.
  Rat   195 TGLKIGGDLTAAVTKTVGTALSSSGMTSIATNNVPPVSSAAPKPTSWAAIARKPAKPQPKL---- 255

  Fly   167 SNSKKK------GPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVPSPPS-PIDLGYSDLSSDFSIS 224
               |.|      |..:||||:   |||:::..||   .|...|.:||: |:
  Rat   256 ---KPKGSVGIGGSAVPPPPI---KHNMNIGTWD---EKGSVVKAPPTQPV-------------- 297

  Fly   225 SNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPRPAT 289
               .||            :..::.           .:..:.|...|:..|..|||   ..|:|..
  Rat   298 ---LPP------------QTIIQQ-----------PQPLIQPPPLVQSQLPQQQP---QPPQPQQ 333

  Fly   290 NAGPFGPPNARRHD-GGPHPS--------RNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEA 345
            ..||  .|.|:.|. ....|.        ||.....|.::..||            ||....|..
  Rat   334 QQGP--QPQAQPHQVQSQQPQLQNRWVAPRNRGTGFNQNNGTGS------------ENFGLGVVP 384

  Fly   346 TSATEELPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTD 408
            .||:.. .|:...||::||..||||||..|  ||   :.|.|:|||||||||||||||.|||||:
  Rat   385 VSASPS-SVEVHPVLEKLKAINNYNPKDFDWNLK---NGRVFIIKSYSEDDIHRSIKYSIWCSTE 445

  Fly   409 HGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWI 473
            |||||||.|::..:.: |.:.|.|||||||||||:|:|.:.||||:.:.|||||||:|||:||||
  Rat   446 HGNKRLDAAYRSLNGK-GPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWI 509

  Fly   474 YVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQE 538
            :||||||..|||||||||:||.|||||||||||.:|..:||:|:.::.|:|||||||.||||:||
  Rat   510 FVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQE 574

  Fly   539 EEVSSKR 545
            ||.:.:|
  Rat   575 EEEAMRR 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	95/135 (70%)
Ythdf3	XP_006232230.1	YTH	420..553	CDD:398013	94/133 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345442
Domainoid	1	1.000	210	1.000	Domainoid score	I2721
eggNOG	1	0.900	-	-		E1_KOG1901
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2746
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000639
OrthoInspector	1	1.000	-	-		otm45474
orthoMCL	1	0.900	-	-		OOG6_102335
Panther	1	1.100	-	-	O	PTHR12357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.790